L-β-threo-benzyl-aspartate

• 产品号: B6436
• CAS号: 871123-98-7(freeacid)
• 分子式: C11H16N2O4
• 分子量: 240.25574
• 纯 度: ≥98% (HPLC)
• 保 存: desiccated

产品别名

• 标题: L-β-threo-benzyl-aspartate ammonium salt
• IUPAC标准名: (2S,3S)-2-amino-3-benzylbutanedioic acid amine
• IUPAC传统名: (2S,3S)-2-amino-3-benzylbutanedioic acid amine
• 别名: (2S,3S)-2-Amino-3-benzylsuccinic ammonium salt; (2S,3S)-2-Amino-3-benzylsuccinic acid; DL-TBOA

产品登记号

• CAS号: 871123-98-7(freeacid)

产品性质

• Empirical Formula (Hill Notation): C11H13NO4 · xNH3
• 纯度: ≥98% (HPLC)
• 外观: white solid
• 溶解度: H2O: >10 mg/mL
• 保存条件: desiccated
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
L-β-threo-benzyl-aspartate is a preferential EAAT3 excitatory amino acid transporter antagonist. The product exhibits 10-fold selectivity for EAAT3, Ki = 0.8 μM for EAAT3 in C17.2 neuroprogenitor cells expressing hEAATs (vs. Ki of 8.7 μM for EAAT1 and Ki of 10 μM for EAAT2). L-β-threo-benzyl-aspartate is a useful tool for studying the EAAT2 pharmacophore.

详细说明 (简体中文)

Biochem/physiol Actions
L-β-threo-benzyl-aspartate is a preferential EAAT3 excitatory amino acid transporter antagonist. The product exhibits 10-fold selectivity for EAAT3, Ki = 0.8 μM for EAAT3 in C17.2 neuroprogenitor cells expressing hEAATs (vs. Ki of 8.7 μM for EAAT1 and Ki of 10 μM for EAAT2). L-β-threo-benzyl-aspartate is a useful tool for studying the EAAT2 pharmacophore.