Biochem/physiol Actions Xylulose-5-phoshate (Xu-5-P) is a metabolite of glucose via the pentose phosphate pathway. In the presence of excess glucose, liver Xu-5-P may act as a signaling molecule that regulates the nuclear transport of carbohydrate response element binding protein (ChREBP), a transcription factor that induces the expression of enzymes involved in glucose metabolism and lipogenesis. Application Xylulose-5-phoshate (Xu-5-P) is an activator of a class of protein phosphatase(s) such as protein phosphatase 2A in rat liver which catalyzed the dephosphorylation of Fru-6-P,2-kinase:Fru-2,6-Pase and protein phosphatases involved in the regulation of carbohydrate-responsive element binding protein (ChREBP) signaling. |