SD-208

• 产品号: S7071
• CAS号: 627536-09-8
• 分子式: C17H10ClFN6
• 分子量: 352.7529032
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: SD-208
• IUPAC标准名: 2-(5-chloro-2-fluorophenyl)-N-(pyridin-4-yl)pteridin-4-amine
• IUPAC传统名: 2-(5-chloro-2-fluorophenyl)-N-(pyridin-4-yl)pteridin-4-amine
• 别名: 2-(5-Chloro-2-fluorophenyl)pteridin-4-yl]pyridin-4-yl-amine

产品登记号

• MDL号: MFCD11519969
• PubChem SID: 24899731
• CAS号: 627536-09-8

产品性质

• Empirical Formula (Hill Notation): C17H10ClFN6
• 纯度: ≥98% (HPLC)
• 外观: off-white to tan powder
• 溶解度: DMSO: >5 mg/mL
• GHS警示词: Warning
• GHS危险声明: H302
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves
• 危险公开号: 22
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
SD-208 is TGF-βR I kinase inhibitor with IC50 =49 nM based on direct enzymatic assay of TGFRI kinase (ALK5) activity with a specificity of >100-fold against TGFRII and at least 17-fold over members of a panel of related protein kinases including p38a, p38b, p38d, JNK1, EGFR, MAPKAPK2, MKK6, ERK2, PKC, PKA, PKD, CDC2, and CaMKII.

详细说明 (简体中文)

Biochem/physiol Actions
SD-208 is TGF-βR I kinase inhibitor with IC50 =49 nM based on direct enzymatic assay of TGFRI kinase (ALK5) activity with a specificity of >100-fold against TGFRII and at least 17-fold over members of a panel of related protein kinases including p38a, p38b, p38d, JNK1, EGFR, MAPKAPK2, MKK6, ERK2, PKC, PKA, PKD, CDC2, and CaMKII.