CyPPA

• 产品号: C5493
• CAS号: 73029-73-9
• 分子式: C16H23N5
• 分子量: 285.38732
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: CyPPA
• IUPAC标准名: N-cyclohexyl-2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methylpyrimidin-4-amine
• IUPAC传统名: N-cyclohexyl-2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-amine
• 别名: Cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine

产品登记号

• MDL号: MFCD01550586
• CAS号: 73029-73-9

产品性质

• Empirical Formula (Hill Notation): C16H23N5
• 纯度: ≥98% (HPLC)
• 外观: white solid
• 溶解度: DMSO: >10 mg/mL
• 溶解度: H2O: <2 mg/mL
• GHS警示词: Warning
• GHS危险声明: H315-H319-H335-H413
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves
• GHS警示性声明: P261-P305 + P351 + P338
• 危险公开号: 36/37/38
• 安全公开号: 26-36/37
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
CyPPA is a positive modulator of small conductance Ca2+-activated K+ channels; selective for SK3 and SK2. CyPPA is a first subtype selective SK channel positive modulator with an EC50 of 5.6 μM and 14 μM, efficacy 90% and 71% for hSK3 and hSK2, respectively. CyPPA is a tool for distinguishing SK2 and SK3 from SK1 and IK; no other agents distinguish these channels.

详细说明 (简体中文)

Biochem/physiol Actions
CyPPA is a positive modulator of small conductance Ca2+-activated K+ channels; selective for SK3 and SK2. CyPPA is a first subtype selective SK channel positive modulator with an EC50 of 5.6 μM and 14 μM, efficacy 90% and 71% for hSK3 and hSK2, respectively. CyPPA is a tool for distinguishing SK2 and SK3 from SK1 and IK; no other agents distinguish these channels.