ICRF-193

• 产品号: I4659
• CAS号: 21416-88-6
• 分子式: C12H18N4O4
• 分子量: 282.29572
• 纯 度: ≥95%

产品别名

• 标题: ICRF-193
• IUPAC标准名: 4-[(2S,3R)-3-(3,5-dioxopiperazin-1-yl)butan-2-yl]piperazine-2,6-dione
• IUPAC传统名: 4-[(2S,3R)-3-(3,5-dioxopiperazin-1-yl)butan-2-yl]piperazine-2,6-dione
• 别名: meso-4,4′-(3,2-butanediyl)-bis(2,6-piperazinedione)

产品登记号

• MDL号: MFCD01702964
• PubChem SID: 24896062
• CAS号: 21416-88-6

产品性质

• Empirical Formula (Hill Notation): C12H18N4O4
• 纯度: ≥95%
• 溶解度: DMSO: soluble4 mg/mL
• GHS警示词: Danger
• GHS危险声明: H301-H317
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• GHS警示性声明: P280-P301 + P310
• RID/ADR: UN 2811 6.1/PG 3
• 危险公开号: 22-43
• RTECS编号: TL6380200
• 安全公开号: 36/37
• 保存温度: -20°C
• 联合国危险货物等级: 6.1
• 联合国危险货物编号: 2811
• 联合国危险货物包装类别(PG): 3
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
ICRF-193 induces a G2 checkpoint that is associated with an ATR-dependent inhibition of polo-like kinase 1 (plk1) activity and a decrease in cyclin B1 phosphorylation.1 Induces apoptosis in several cell lines including K562 and Molt-4 cells.2,,,1 ICRF-193 is a topoisomerase II inhibitor, more potent against topoisomerase II-β than topoisomerase II-α3, and may in addition cause DNA strand breaks.4

详细说明 (简体中文)

Biochem/physiol Actions
ICRF-193 induces a G2 checkpoint that is associated with an ATR-dependent inhibition of polo-like kinase 1 (plk1) activity and a decrease in cyclin B1 phosphorylation.1 Induces apoptosis in several cell lines including K562 and Molt-4 cells.2,,,1 ICRF-193 is a topoisomerase II inhibitor, more potent against topoisomerase II-β than topoisomerase II-α3, and may in addition cause DNA strand breaks.4