CI 976

• 产品号: C3743
• CAS号: 114289-47-3
• 分子式: C23H39NO4
• 分子量: 393.56006
• 纯 度: >98% (HPLC)

产品别名

• 标题: CI 976
• IUPAC标准名: 2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide
• IUPAC传统名: 2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide
• 别名: 2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide

产品登记号

• CAS号: 114289-47-3
• MDL号: MFCD00869662

产品性质

• Empirical Formula (Hill Notation): C23H39NO4
• 纯度: >98% (HPLC)
• 外观: solid
• 溶解度: DMSO: >10 mg/mL
• 溶解度: H2O: insoluble <2 mg/mL
• GHS危险声明: H413
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
CI-976, a new trimethoxy fatty acid anilide, is a potent and specific inhibitor of liver and intestinal acyl coenzyme A; cholesterol acyltransferase (ACAT) in vitro. CI-976 decreased non-high density lipoprotein (HDL)-cholesterol and increased HDL-cholesterol in rats with pre-established dyslipidemia. High performance gel chromatographic separation of plasma lipoproteins also revealed that CI-976, but not CL 277,082, lowered low density lipoprotein (LDL)-cholesterol and elevated HDL-cholesterol.

详细说明 (简体中文)

Biochem/physiol Actions
CI-976, a new trimethoxy fatty acid anilide, is a potent and specific inhibitor of liver and intestinal acyl coenzyme A; cholesterol acyltransferase (ACAT) in vitro. CI-976 decreased non-high density lipoprotein (HDL)-cholesterol and increased HDL-cholesterol in rats with pre-established dyslipidemia. High performance gel chromatographic separation of plasma lipoproteins also revealed that CI-976, but not CL 277,082, lowered low density lipoprotein (LDL)-cholesterol and elevated HDL-cholesterol.