RG108

• 产品号: R8279
• CAS号: 48208-26-0
• 分子式: C19H16N2O4
• 分子量: 336.34134
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: RG108
• IUPAC标准名: (2S)-2-(1,3-dioxo-2,3,5,6-tetrahydro-1H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid
• IUPAC传统名: (2S)-2-(1,3-dioxo-5,6-dihydroisoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid
• 别名: N-Phthalyl-L-tryptophan

产品登记号

• CAS号: 48208-26-0
• PubChem SID: 24724594

产品性质

• Empirical Formula (Hill Notation): C19H14N2O4
• 纯度: ≥98% (HPLC)
• 外观: yellow powder
• 溶解度: DMSO: >10 mg/mL
• 保存温度: -20°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
RG108 is a DNA methyltransferase (DMNT) inhibitor. It reactivates tumor suppressor gene expression (p16, SFRP1, secreted frizzled related protein-1, and TIMP-3) in tumor cells by DNA demethylation. RG108 also inhibits human tumor cell line (HCT116, NALM-6) proliferation and increased doubling time in culture.

详细说明 (简体中文)

Biochem/physiol Actions
RG108 is a DNA methyltransferase (DMNT) inhibitor. It reactivates tumor suppressor gene expression (p16, SFRP1, secreted frizzled related protein-1, and TIMP-3) in tumor cells by DNA demethylation. RG108 also inhibits human tumor cell line (HCT116, NALM-6) proliferation and increased doubling time in culture.