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Cilnidipine

产品号 C1493 公司名称 Sigma Aldrich
CAS号 132203-70-4 公司网站 http://www.sigmaaldrich.com
分子式 C27H28N2O7 电 话 1-800-521-8956
分子量 492.52042 传 真
纯 度 ≥98% (HPLC) 电子邮件
保 存 protect from light Chembase数据库ID: 72614

产品价格信息

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产品别名

标题
Cilnidipine
IUPAC标准名
3-(2-methoxyethyl) 5-(3-phenylprop-2-en-1-yl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
IUPAC传统名
3-(2-methoxyethyl) 5-(3-phenylprop-2-en-1-yl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
别名
FRC 8653
1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl (2E)-3-phenyl-2-propenyl ester

产品登记号

MDL号 MFCD00865853
PubChem SID 24892414
CAS号 132203-70-4

产品性质

个人保护装置 dust mask type N95 (US), Eyeshields, Gloves
GHS警示性声明 P280-P305 + P351 + P338
危险公开号 41
RTECS编号 US7975550
安全公开号 26-39
保存条件 protect from light
德国WGK号 3
GHS危险品标识 GHS05
GHS警示词 Danger
GHS危险声明 H318
欧盟危险性物质标志 刺激性(Irritant) 刺激性(Irritant) (Xi)
MSDS下载 下载链接
Empirical Formula (Hill Notation) C27H28N2O7
纯度 ≥98% (HPLC)
外观 light yellow powder
溶解度 H2O: ≤2 mg/mL
溶解度 DMSO: ≥20 mg/mL

产品详细信息

详细说明 (English)
Packaging
Protect from high temperatures.
Biochem/physiol Actions
Cilnidipine is a slow-acting Ca2+ channel blocker; antihypertensive; vasodilator; dual blocker of L-type voltage-gated Ca2+ channels in vascular smooth muscle and N-type Ca2+ channels in sympathetic nerve terminals that supply blood vessels. Cilnidipine may offer an advantage over nifedipine as the long term intake of the latter has been linked to increased risk of myocardial infarction and mortality in patients with coronary artery disease. Cilnidipine lowers blood pressure, but has less effect on sympathetic activity. Unlike nifedipine, cilnidipine does not inhibit PKC.
详细说明 (简体中文)
包装
Protect from high temperatures.
Biochem/physiol Actions
Cilnidipine is a slow-acting Ca2+ channel blocker; antihypertensive; vasodilator; dual blocker of L-type voltage-gated Ca2+ channels in vascular smooth muscle and N-type Ca2+ channels in sympathetic nerve terminals that supply blood vessels. Cilnidipine may offer an advantage over nifedipine as the long term intake of the latter has been linked to increased risk of myocardial infarction and mortality in patients with coronary artery disease. Cilnidipine lowers blood pressure, but has less effect on sympathetic activity. Unlike nifedipine, cilnidipine does not inhibit PKC.

参考文献