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CHIC-35_分子结构_CAS_848193-72-6)
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CHIC-35

产品号 C8742 公司名称 Sigma Aldrich
CAS号 848193-72-6 公司网站 http://www.sigmaaldrich.com
分子式 C14H15ClN2O 电 话 1-800-521-8956
分子量 262.7347 传 真
纯 度 ≥97% (chiral, HPLC) 电子邮件
保 存 Chembase数据库ID: 153948

产品价格信息

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产品别名

标题
CHIC-35
IUPAC标准名
(6S)-2-chloro-5H,6H,7H,8H,9H,10H-cyclohepta[b]indole-6-carboxamide
IUPAC传统名
(6S)-2-chloro-5H,6H,7H,8H,9H,10H-cyclohepta[b]indole-6-carboxamide
别名
(6S)-2-Chloro-5,6,7,8,9,10-hexahydro-cyclohept[b]indole-6-carboxamide
Compound (S)-35

产品登记号

CAS号 848193-72-6

产品性质

Empirical Formula (Hill Notation) C14H15ClN2O
纯度 ≥97% (chiral, HPLC)
外观 solid
溶解度 DMSO: >10 mg/mL
溶解度 H2O: <2 mg/mL
GHS危险品标识 GHS06
GHS警示词 Danger
GHS危险声明 H301-H315-H319-H335
欧盟危险性物质标志 有害性(Harmful) 有害性(Harmful) (Xn)
MSDS下载 下载链接
个人保护装置 dust mask type N95 (US), Eyeshields, Faceshields, Gloves
GHS警示性声明 P261-P301 + P310-P305 + P351 + P338
RID/ADR UN 2811 6.1/PG 3
危险公开号 36/37/38
安全公开号 26
保存温度 2-8°C
联合国危险货物等级 6.1
联合国危险货物编号 2811
联合国危险货物包装类别(PG) 3
德国WGK号 3

产品详细信息

详细说明 (English)
Biochem/physiol Actions
CHIC-35 is cell-permeable, metabolically stable, and very potent inhibitor of SIRT1; IC50 of S-isomer is 60 nM; IC50 of mixed isomers is 124 nM. There is no inhibition of SIRT3 or HDAC. The IC50 for SIRT2 is 2.77 μM. Sirtuins are protein deacetylases, which represent a new class of histone deacetylases (HDAC) involved in gene silencing. SIRT modulators are potential therapeutics for cancer, diabetes, muscle differentiation, heart failure, neurodegeneration, and aging.
详细说明 (简体中文)
Biochem/physiol Actions
CHIC-35 is cell-permeable, metabolically stable, and very potent inhibitor of SIRT1; IC50 of S-isomer is 60 nM; IC50 of mixed isomers is 124 nM. There is no inhibition of SIRT3 or HDAC. The IC50 for SIRT2 is 2.77 μM. Sirtuins are protein deacetylases, which represent a new class of histone deacetylases (HDAC) involved in gene silencing. SIRT modulators are potential therapeutics for cancer, diabetes, muscle differentiation, heart failure, neurodegeneration, and aging.

参考文献