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Org 24598 lithium salt_分子结构_CAS_722456-08-8)
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Org 24598 lithium salt

产品号 O7639 公司名称 Sigma Aldrich
CAS号 722456-08-8 公司网站 http://www.sigmaaldrich.com
分子式 C19H19F3LiNO3 电 话 1-800-521-8956
分子量 373.2952696 传 真
纯 度 ≥98% (HPLC) 电子邮件
保 存 Chembase数据库ID: 153947

产品价格信息

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产品别名

标题
Org 24598 lithium salt
IUPAC标准名
lithium(1+) ion 2-{methyl[(3R)-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl]amino}acetate
IUPAC传统名
lithium(1+) ion 2-{methyl[(3R)-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl]amino}acetate
别名
R-(-)-N-Methyl-N-[3-[(4-trifluoromethyl)phenoxy]-3-phenyl-propyl]glycine lithium salt

产品登记号

MDL号 MFCD08705419
PubChem SID 24898046
CAS号 722456-08-8

产品性质

Empirical Formula (Hill Notation) C19H19F3LiNO3
纯度 ≥98% (HPLC)
外观 white to off-white solid
溶解度 H2O: >2 mg/mL
MSDS下载 下载链接
保存温度 2-8°C
德国WGK号 3

产品详细信息

详细说明 (English)
Biochem/physiol Actions
Org 24598 is a selective, potent inhibitor of glial GlyT (GlyT1, glycine transporter type 1). In rats (P12-P16) and in the presence of kynurenic acid, 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and bicuculline, ORG 24598 at a concentration of 10 μM induced a mean inward current of -10/-50 pA at -60 mV and increased significantly the decay time constants of miniature (mIPSCs), spontaneous (sIPSCs) and electrically evoked glycinergic (eIPSCs) inhibitory postsynaptic currents. Replacing extracellular sodium with N-methyl-d-glucamine or superfusing the slice with micromolar concentrations of glycine also increased the decay time constant of glycinergic IPSCs. Glycine (1-5 μM and d-serine (10 μM) increased the amplitude of eEPSCs whereas l-serine had no effect. Org 24598 increased significantly the amplitude of NMDA receptor-mediated eEPSCs without affecting the amplitude of non-NMDA receptor-mediated eEPSCs. This brings conclusion that blocking glial glycine transporter by Org 24598 increased the level of glycine in spinal cord slices, which in turn prolonged the duration of glycinergic synaptic current and potentiated the NMDA-mediated synaptic response.
详细说明 (简体中文)
Biochem/physiol Actions
Org 24598 is a selective, potent inhibitor of glial GlyT (GlyT1, glycine transporter type 1). In rats (P12-P16) and in the presence of kynurenic acid, 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and bicuculline, ORG 24598 at a concentration of 10 μM induced a mean inward current of -10/-50 pA at -60 mV and increased significantly the decay time constants of miniature (mIPSCs), spontaneous (sIPSCs) and electrically evoked glycinergic (eIPSCs) inhibitory postsynaptic currents. Replacing extracellular sodium with N-methyl-d-glucamine or superfusing the slice with micromolar concentrations of glycine also increased the decay time constant of glycinergic IPSCs. Glycine (1-5 μM and d-serine (10 μM) increased the amplitude of eEPSCs whereas l-serine had no effect. Org 24598 increased significantly the amplitude of NMDA receptor-mediated eEPSCs without affecting the amplitude of non-NMDA receptor-mediated eEPSCs. This brings conclusion that blocking glial glycine transporter by Org 24598 increased the level of glycine in spinal cord slices, which in turn prolonged the duration of glycinergic synaptic current and potentiated the NMDA-mediated synaptic response.

参考文献