Xli 093 hydrate

• 产品号: X4628
• CAS号: 646066-59-3(anhydrous)
• 分子式: C33H28N6O7
• 分子量: 620.61142
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: Xli 093 hydrate
• IUPAC标准名: 3-{12-ethynyl-8-methyl-9-oxo-2,4,8-triazatricyclo[8.4.0.0^2,^6]tetradeca-1(14),3,5,10,12-pentaene-5-carbonyloxy}propyl 12-ethynyl-8-methyl-9-oxo-2,4,8-triazatricyclo[8.4.0.0^2,^6]tetradeca-1(14),3,5,10,12-pentaene-5-carboxylate hydrate
• IUPAC传统名: 3-{12-ethynyl-8-methyl-9-oxo-2,4,8-triazatricyclo[8.4.0.0^2,^6]tetradeca-1(14),3,5,10,12-pentaene-5-carbonyloxy}propyl 12-ethynyl-8-methyl-9-oxo-2,4,8-triazatricyclo[8.4.0.0^2,^6]tetradeca-1(14),3,5,10,12-pentaene-5-carboxylate hydrate
• 别名: Bis[8-ethynyl-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid] 1,3-propanediyl ester hydrate

产品登记号

• CAS号: 646066-59-3(anhydrous)
• PubChem SID: 24724668
• MDL号: MFCD08705422

产品性质

• Empirical Formula (Hill Notation): C33H26N6O6 · xH2O
• 纯度: ≥98% (HPLC)
• 外观: off-white powder
• 溶解度: DMSO: ~16 mg/mL
• 溶解度: H2O: insoluble
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Xli 093 is α5 subtype selective benzodiazepine/GABAA receptor antagonist. Xli 093 shows Ki = 5 nM at the α5 receptor in Ltk- cell membranes expressing human α5β3γ2 receptors; little or no affinity at other BDZ/ GABAA subtypes; does not trigger chloride currents in any subtype of tested subtypes, up to 1 μM in concentration; dose-dependently and completely inhibits diazepam stimulated currents in α5β3γ2 receptors.

详细说明 (简体中文)

Biochem/physiol Actions
Xli 093 is α5 subtype selective benzodiazepine/GABAA receptor antagonist. Xli 093 shows Ki = 5 nM at the α5 receptor in Ltk- cell membranes expressing human α5β3γ2 receptors; little or no affinity at other BDZ/ GABAA subtypes; does not trigger chloride currents in any subtype of tested subtypes, up to 1 μM in concentration; dose-dependently and completely inhibits diazepam stimulated currents in α5β3γ2 receptors.