Cucurbitacin I

• 产品号: C4493
• CAS号: 2222-07-3(anhydrous)
• 分子式: C30H44O8
• 分子量: 532.66556
• 纯 度: ≥97% (HPLC)

产品别名

• 标题: Cucurbitacin I hydrate
• IUPAC标准名: (1R,2R,10S,11S,13R,14R,15R)-14-[(2R)-2,6-dihydroxy-6-methyl-3-oxohept-4-en-2-yl]-4,13-dihydroxy-1,6,6,11,15-pentamethyltetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadeca-3,7-diene-5,17-dione hydrate
• IUPAC传统名: (1R,2R,10S,11S,13R,14R,15R)-14-[(2R)-2,6-dihydroxy-6-methyl-3-oxohept-4-en-2-yl]-4,13-dihydroxy-1,6,6,11,15-pentamethyltetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadeca-3,7-diene-5,17-dione hydrate
• 别名: 2,16α,20,25-tetrahydroxy-9-methyl-19-Nor-9β,10α-lanosta-1,5,23-triene-3,11,22-trione; Elatericin B; NSC 521777; JSI-124

产品登记号

• CAS号: 2222-07-3(anhydrous)
• EC号: 218-736-8

产品性质

• Empirical Formula (Hill Notation): C30H42O7 · xH2O
• 纯度: ≥97% (HPLC)
• 外观: white to off-white solid
• 溶解度: DMSO: >5 mg/mL
• GHS警示词: Danger
• GHS危险声明: H300
• 欧盟危险性物质标志: 剧毒(Highly toxic) (T+)
• 个人保护装置: Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS警示性声明: P264-P301 + P310
• RID/ADR: UN 2811 6.1/PG 1
• 危险公开号: 28
• RTECS编号: RC6200000
• 安全公开号: 28-36/37-45
• 保存温度: -20°C
• 联合国危险货物等级: 6.1
• 联合国危险货物编号: 2811
• 联合国危险货物包装类别(PG): 1
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Cucurbitacin I (JSI-124) is a novel selective inhibitor of the janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) signaling pathway with anti-proliferative and anti-tumor properties.

详细说明 (简体中文)

Biochem/physiol Actions
Cucurbitacin I (JSI-124) is a novel selective inhibitor of the janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) signaling pathway with anti-proliferative and anti-tumor properties.