KR-62436 hydrate

• 产品号: K4264
• CAS号: 761414-79-3(freebase)
• 分子式: C14H19Cl2N7O2
• 分子量: 388.25236
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: KR-62436 hydrate
• IUPAC标准名: 6-[(2-{[2-(5-cyano-4,5-dihydro-1H-pyrazol-1-yl)-2-oxoethyl]amino}ethyl)amino]pyridine-3-carbonitrile hydrate dihydrochloride
• IUPAC传统名: 6-[(2-{[2-(5-cyano-4,5-dihydropyrazol-1-yl)-2-oxoethyl]amino}ethyl)amino]pyridine-3-carbonitrile hydrate dihydrochloride
• 别名: 6-{2-[(5-Cyano-4,5-dihydropyrazol-1-yl)-2-oxoethylamino]ethylamino}nicotinonitrile dihydrochloride hydrate

产品登记号

• CAS号: 761414-79-3(freebase)
• MDL号: MFCD17215675
• PubChem SID: 24724521

产品性质

• Empirical Formula (Hill Notation): C14H15N7O·2HCl · xH2O
• 纯度: ≥98% (HPLC)
• 外观: light tan solid
• 溶解度: DMSO: >10 mg/mL
• 溶解度: H2O: >5 mg/mL
• GHS警示词: Warning
• GHS危险声明: H302
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• 危险公开号: 22
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
KR-62436 is a competitive inhibitor of dipeptidyl peptidase-IV (DPP-IV). DPP-IV is a serine protease which inactivates glucagon-like peptide (GLP-1); IC50 0.1-0.8 μM; GLP-1 is a potent stimulus for insulin secretion and inducer of satiety after food intake, but it has a very short action (1 min) because it is rapidly degraded by DPP-IV; blocking DPP-IV increases GLP-1 action and increases plasma insulin levels; DPP-IV inhibitors and KR-62436 have clinical potential as anti-diabetic agents

详细说明 (简体中文)

Biochem/physiol Actions
KR-62436 is a competitive inhibitor of dipeptidyl peptidase-IV (DPP-IV). DPP-IV is a serine protease which inactivates glucagon-like peptide (GLP-1); IC50 0.1-0.8 μM; GLP-1 is a potent stimulus for insulin secretion and inducer of satiety after food intake, but it has a very short action (1 min) because it is rapidly degraded by DPP-IV; blocking DPP-IV increases GLP-1 action and increases plasma insulin levels; DPP-IV inhibitors and KR-62436 have clinical potential as anti-diabetic agents