AR-A014418

• 产品号: A3230
• CAS号: 487021-52-3
• 分子式: C12H12N4O4S
• 分子量: 308.31308
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: AR-A014418
• IUPAC标准名: 1-[(4-methoxyphenyl)methyl]-3-(5-nitro-1,3-thiazol-2-yl)urea
• IUPAC传统名: 1-[(4-methoxyphenyl)methyl]-3-(5-nitro-1,3-thiazol-2-yl)urea
• 别名: N-(4-Methoxybenzyl)-N′-(5-nitro-1,3-thiazol-2-yl)urea

产品登记号

• CAS号: 487021-52-3
• MDL号: MFCD08277040

产品性质

• Empirical Formula (Hill Notation): C12H12N4O4S
• 纯度: ≥98% (HPLC)
• 外观: off-white to tan solid
• 溶解度: DMSO: ≥20 mg/mL, clear, light yellow
• 溶解度: H2O: insoluble
• GHS警示词: Danger
• GHS危险声明: H302-H315-H318-H335
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves
• GHS警示性声明: P261-P280-P305 + P351 + P338
• 危险公开号: 22-37/38-41
• 安全公开号: 26-36/39
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Glycogen synthase kinase 3 (GSK3) is a serine/threonine kinase that has been implicated in pathological conditions such as diabetes and Alzheimer′s disease. GSK3 inhibitor, AR-A014418, inhibits GSK3 (IC50 = 104 nM), in an ATP-competitive manner (Ki = 38 nM). AR-A014418 does not significantly inhibit cdk2 or cdk5 (IC50 > 100 μM) or 26 other kinases, demonstrating high specificity for GSK3.

详细说明 (简体中文)

Biochem/physiol Actions
Glycogen synthase kinase 3 (GSK3) is a serine/threonine kinase that has been implicated in pathological conditions such as diabetes and Alzheimer′s disease. GSK3 inhibitor, AR-A014418, inhibits GSK3 (IC50 = 104 nM), in an ATP-competitive manner (Ki = 38 nM). AR-A014418 does not significantly inhibit cdk2 or cdk5 (IC50 > 100 μM) or 26 other kinases, demonstrating high specificity for GSK3.