CFTR(inh)-172

• 产品号: C2992
• CAS号: 307510-92-5
• 分子式: C18H10F3NO3S2
• 分子量: 409.4021096
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: CFTR(inh)-172
• IUPAC标准名: 4-({4-oxo-2-sulfanylidene-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene}methyl)benzoic acid
• IUPAC传统名: 4-({4-oxo-2-sulfanylidene-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene}methyl)benzoic acid
• 别名: 5-[(4-Carboxyphenyl)methylene]-2-thioxo-3-[(3-trifluoromethyl)phenyl-4-thiazolidinone

产品登记号

• MDL号: MFCD06411408
• CAS号: 307510-92-5
• PubChem SID: 24724436

产品性质

• Empirical Formula (Hill Notation): C18H10F3NO3S2
• 纯度: ≥98% (HPLC)
• 外观: yellow powder
• 溶解度: DMSO: ≥10 mg/mL
• 溶解度: H2O: insoluble
• GHS警示词: Warning
• GHS危险声明: H315-H317-H319-H335-H410
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• 欧盟危险性物质标志: 环境危害性(Nature polluting) (N)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• GHS警示性声明: P261-P273-P280-P305 + P351 + P338-P501
• RID/ADR: UN 3077 9/PG 3
• 危险公开号: 36/37/38-43-50/53
• 安全公开号: 26-36/37-60-61
• 保存温度: 2-8°C
• 联合国危险货物等级: 9
• 联合国危险货物编号: 3077
• 联合国危险货物包装类别(PG): 3
• 德国WGK号: 3

产品详细信息

详细说明 (简体中文)

Biochem/physiol Actions
CFTR(inh)-172 is an inhibitor of the cystic fibrosis transmembrane conductance regulator (CFTR). With a Ki = 300 nM,. CFTR(inh)-172 leads to rapid, reversible and voltage-independent inhibition; it is an antidiarrheal agent in animals. CTFR(inh)-172 may be a useful tool to study animal models of cystic fibrosis and intestinal fluid loss in cholera and other secretory diarrheas. CTFR(inh)-172 is structurally-unrelated to known, but non-specific CFTR inhibitors DPC, NPPB (Cat. No. N4779) and Glibenclamide.

详细说明 (English)

Biochem/physiol Actions
CFTR(inh)-172 is an inhibitor of the cystic fibrosis transmembrane conductance regulator (CFTR). With a Ki = 300 nM,. CFTR(inh)-172 leads to rapid, reversible and voltage-independent inhibition; it is an antidiarrheal agent in animals. CTFR(inh)-172 may be a useful tool to study animal models of cystic fibrosis and intestinal fluid loss in cholera and other secretory diarrheas. CTFR(inh)-172 is structurally-unrelated to known, but non-specific CFTR inhibitors DPC, NPPB (Cat. No. N4779) and Glibenclamide.