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Chk2 Inhibitor II hydrate

产品号 C3742 公司名称 Sigma Aldrich
CAS号 516480-79-8(anhydrous) 公司网站 http://www.sigmaaldrich.com
分子式 C20H14ClN3O2 电 话 1-800-521-8956
分子量 363.79706 传 真
纯 度 ≥98% (HPLC) 电子邮件
保 存 Chembase数据库ID: 153932

产品价格信息

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产品别名

标题
Chk2 Inhibitor II hydrate
IUPAC标准名
2-[4-(4-chlorophenoxy)phenyl]-1H-1,3-benzodiazole-5-carboxamide
IUPAC传统名
2-[4-(4-chlorophenoxy)phenyl]-1H-1,3-benzodiazole-5-carboxamide
别名
2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide hydrate

产品登记号

MDL号 MFCD08276917
PubChem SID 24724438
CAS号 516480-79-8(anhydrous)

产品性质

Empirical Formula (Hill Notation) C20H14ClN3O2 · xH2O
纯度 ≥98% (HPLC)
相关基因信息 human ... CHEK2(11200)
外观 off-white to tan solid
溶解度 DMSO: >10 mg/mL
MSDS下载 下载链接
保存温度 2-8°C
德国WGK号 3

产品详细信息

详细说明 (English)
Biochem/physiol Actions
Chk2 Inhibitor II is a checkpoint kinase 2 inhibitor, which controls the p53 response to DNA breaks induced by radiation, leading to apoptosis. Protection of T-cells from apoptosis implies use as an adjuvant for radiation therapy in cancer. IC50 = 15 nM; Ki = 37 nM. Chk2 Inhibitor II shows 1000-fold greater selectivity for the Chk2 serine/threonine kinase than for the Cdk1/B and CK1 kinases (for which IC50 = 12 μM and 17 μM, respectively). Chk2 Inhibitor II weakly inhibits a panel of 31 other kinases (<25% inhibition at a concentration of 10 μM and prevents apoptosis of human CD4+ and CD8+ T-cells subjected to ionizing radiation (EC50 = 3 μM and 7.6 μM, respectively).
详细说明 (简体中文)
Biochem/physiol Actions
Chk2 Inhibitor II is a checkpoint kinase 2 inhibitor, which controls the p53 response to DNA breaks induced by radiation, leading to apoptosis. Protection of T-cells from apoptosis implies use as an adjuvant for radiation therapy in cancer. IC50 = 15 nM; Ki = 37 nM. Chk2 Inhibitor II shows 1000-fold greater selectivity for the Chk2 serine/threonine kinase than for the Cdk1/B and CK1 kinases (for which IC50 = 12 μM and 17 μM, respectively). Chk2 Inhibitor II weakly inhibits a panel of 31 other kinases (<25% inhibition at a concentration of 10 μM and prevents apoptosis of human CD4+ and CD8+ T-cells subjected to ionizing radiation (EC50 = 3 μM and 7.6 μM, respectively).

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