Tubulysin A

• 产品号: T3327
• CAS号: 205304-86-5
• 分子式: C43H65N5O10S
• 分子量: 844.0687
• 纯 度: ≥95% (HPLC)

产品别名

• 标题: Tubulysin A
• IUPAC标准名: (2S,4R)-4-({2-[(1R,3R)-1-(acetyloxy)-4-methyl-3-[(2S,3S)-3-methyl-N-{[(3-methylbutanoyl)oxy]methyl}-2-{[(2R)-1-methylpiperidin-2-yl]formamido}pentanamido]pentyl]-1,3-thiazol-4-yl}formamido)-5-(4-hydroxyphenyl)-2-methylpentanoic acid
• IUPAC传统名: (2S,4R)-4-({2-[(1R,3R)-1-(acetyloxy)-4-methyl-3-[(2S,3S)-3-methyl-N-{[(3-methylbutanoyl)oxy]methyl}-2-{[(2R)-1-methylpiperidin-2-yl]formamido}pentanamido]pentyl]-1,3-thiazol-4-yl}formamido)-5-(4-hydroxyphenyl)-2-methylpentanoic acid
• 别名: TubA

产品登记号

• MDL号: MFCD12912448
• CAS号: 205304-86-5

产品性质

• 生物来源: from Streptomyces sp.
• Empirical Formula (Hill Notation): C43H65N5O10S
• 纯度: ≥95% (HPLC)
• 运输包装: wet ice
• 外观: colorless or white film
• 溶解度: organic solvents: soluble
• GHS警示词: Danger
• GHS危险声明: H301-H311-H315-H319-H331-H335
• 欧盟危险性物质标志: 有毒(Toxic) (T)
• 个人保护装置: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
• GHS警示性声明: P261-P280-P301 + P310-P305 + P351 + P338-P311
• 危险公开号: 23/24/25-36/37/38
• 安全公开号: 36/37-45
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Tubulysin A is a novel antibiotic, which is anti-microtubule, anti-mitotic, apoptosis inducer, anticancer, anti-angiogenic, and antiproliferative. Tubulysins are cytotoxic peptides, which include 9 members (A-I). Tubulysin A has potential application as an anticancer agent. It arrests cells in the G2/M phase. Tubulysin A inhibits polymerization more efficiently than vinblastine and induces depolymerization of isolated microtubules. Tubulysin A has potent cytostatic effects on various tumor cell lines with IC50 in the picomolar range.

详细说明 (简体中文)

Biochem/physiol Actions
Tubulysin A is a novel antibiotic, which is anti-microtubule, anti-mitotic, apoptosis inducer, anticancer, anti-angiogenic, and antiproliferative. Tubulysins are cytotoxic peptides, which include 9 members (A-I). Tubulysin A has potential application as an anticancer agent. It arrests cells in the G2/M phase. Tubulysin A inhibits polymerization more efficiently than vinblastine and induces depolymerization of isolated microtubules. Tubulysin A has potent cytostatic effects on various tumor cell lines with IC50 in the picomolar range.