Sordarin sodium salt 钠盐

• 产品号: S1442
• CAS号: 463356-00-5
• 分子式: C27H39NaO8
• 分子量: 514.58353
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: Sordarin sodium salt
• IUPAC标准名: sodium (1R,2S,4R,5R,8R,9S,11R)-2-({[(2R,3S,4S,5S,6R)-3,4-dihydroxy-5-methoxy-6-methyloxan-2-yl]oxy}methyl)-9-formyl-5-methyl-13-(propan-2-yl)tetracyclo[7.4.0.0^2,^1^1.0^4,^8]tridec-12-ene-1-carboxylate
• IUPAC传统名: sodium (1R,2S,4R,5R,8R,9S,11R)-2-({[(2R,3S,4S,5S,6R)-3,4-dihydroxy-5-methoxy-6-methyloxan-2-yl]oxy}methyl)-9-formyl-13-isopropyl-5-methyltetracyclo[7.4.0.0^2,^1^1.0^4,^8]tridec-12-ene-1-carboxylate

产品登记号

• PubChem SID: 24899480
• CAS号: 463356-00-5
• MDL号: MFCD08277029

产品性质

• 生物来源: from Sordaria araneosa
• Empirical Formula (Hill Notation): C27H39NaO8
• 纯度: ≥98% (HPLC)
• 运输包装: wet ice
• 外观: solid
• 溶解度: H2O: soluble ≤10 mg/mL
• 德国WGK号: 3
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• 保存温度: -20°C

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Sordarin is an antifungal metabolite possessing a tetracyclic diterpene glycoside structure. It is a highly potent inhibitor of eukaryotic protein synthesis with selectivity for the fungal translation machinery. The elongation factor EF-2 is the molecular target for sordarin. It blocks ribosomal translocation by stabilizing the EF2-ribosome complex in a manner similar to that of fusidic acid in the bacterial system. Additional cellular components (including rpP0, which is an essential protein of the ribosomal large subunit stalk) are involved in its mechanism of action. Sordarin inhibits in vitro translation in the pathogenic fungi C. albicans, C. glabrata, and C. neoformans. In addition to its therapeutic potential, sordarin is a useful tool for the analysis of protein translation events.

详细说明 (简体中文)

Biochem/physiol Actions
Sordarin is an antifungal metabolite possessing a tetracyclic diterpene glycoside structure. It is a highly potent inhibitor of eukaryotic protein synthesis with selectivity for the fungal translation machinery. The elongation factor EF-2 is the molecular target for sordarin. It blocks ribosomal translocation by stabilizing the EF2-ribosome complex in a manner similar to that of fusidic acid in the bacterial system. Additional cellular components (including rpP0, which is an essential protein of the ribosomal large subunit stalk) are involved in its mechanism of action. Sordarin inhibits in vitro translation in the pathogenic fungi C. albicans, C. glabrata, and C. neoformans. In addition to its therapeutic potential, sordarin is a useful tool for the analysis of protein translation events.