JNJ-10198409

• 产品号: J4649
• CAS号: 627518-40-5
• 分子式: C18H16FN3O2
• 分子量: 325.3369432
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: JNJ-10198409
• IUPAC标准名: N-(3-fluorophenyl)-6,7-dimethoxy-1H,4H-indeno[1,2-c]pyrazol-3-amine
• IUPAC传统名: N-(3-fluorophenyl)-6,7-dimethoxy-1H,4H-indeno[1,2-c]pyrazol-3-amine
• 别名: N-(3-fluorophenyl)-2,4-dihydro-6,7-dimethoxy-Indeno[1,2-c]pyrazol-3-amine; RWJ 540973; 3-Fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamine

产品登记号

• CAS号: 627518-40-5

产品性质

• Empirical Formula (Hill Notation): C18H16FN3O2
• 纯度: ≥98% (HPLC)
• 外观: off-white solid
• 溶解度: DMSO: >10 mg/mL
• 溶解度: H2O: <2 mg/mL
• 保存温度: -20°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
JNJ-10198409 is a potent ATP-competitive inhibitor of Platelet-Derived Growth Factor receptor tyrosine kinase (PDGF-RTK) with both antiangiogenic and a direct tumor cell antiproliferative activity. It is selective for PDGF-β kinase with IC50 values of 4.2 nM for PDGF-β and 45 nM for PDGF-α kinase.

详细说明 (简体中文)

Biochem/physiol Actions
JNJ-10198409 is a potent ATP-competitive inhibitor of Platelet-Derived Growth Factor receptor tyrosine kinase (PDGF-RTK) with both antiangiogenic and a direct tumor cell antiproliferative activity. It is selective for PDGF-β kinase with IC50 values of 4.2 nM for PDGF-β and 45 nM for PDGF-α kinase.