TPCA-1

• 产品号: T1452
• CAS号: 507475-17-4
• 分子式: C12H10FN3O2S
• 分子量: 279.2901032
• 纯 度: ≥95% (HPLC)

产品别名

• 标题: TPCA-1
• IUPAC标准名: 2-(carbamoylamino)-5-(4-fluorophenyl)thiophene-3-carboxamide
• IUPAC传统名: 2-(carbamoylamino)-5-(4-fluorophenyl)thiophene-3-carboxamide
• 别名: GW683965; GW683965A; [5-(p-Fluorophenyl)-2-ureido]thiophene-3-carboxamide

产品登记号

• CAS号: 507475-17-4
• MDL号: MFCD09037541

产品性质

• Empirical Formula (Hill Notation): C12H10FN3O2S
• 纯度: ≥95% (HPLC)
• 外观: off-white powder
• 溶解度: DMSO: ≥10 mg/mL
• 溶解度: H2O: insoluble
• GHS警示词: Warning
• GHS危险声明: H302-H319
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves
• GHS警示性声明: P305 + P351 + P338
• 危险公开号: 22-36
• 安全公开号: 26
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
TPCA-1 is a potent and selective inhibitor of human IκB kinase-2 (IKK-2) with IC50 = 17.9 nM for IKK-2 compared to 400nm for IKK-1. It has been used to study inhibition of IKK-2 to prevent inflammatory mediator release in animal models of arthritis and airway inflammation.

详细说明 (简体中文)

Biochem/physiol Actions
TPCA-1 is a potent and selective inhibitor of human IκB kinase-2 (IKK-2) with IC50 = 17.9 nM for IKK-2 compared to 400nm for IKK-1. It has been used to study inhibition of IKK-2 to prevent inflammatory mediator release in animal models of arthritis and airway inflammation.