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Org 27569

产品号 O8014 公司名称 Sigma Aldrich
CAS号 868273-06-7 公司网站 http://www.sigmaaldrich.com
分子式 C24H28ClN3O 电 话 1-800-521-8956
分子量 409.95162 传 真
纯 度 ≥98% (HPLC) 电子邮件
保 存 Chembase数据库ID: 73142

产品价格信息

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产品别名

标题
Org 27569
IUPAC标准名
5-chloro-3-ethyl-N-{2-[4-(piperidin-1-yl)phenyl]ethyl}-1H-indole-2-carboxamide
IUPAC传统名
5-chloro-3-ethyl-N-{2-[4-(piperidin-1-yl)phenyl]ethyl}-1H-indole-2-carboxamide
别名
5-chloro-3-ethyl-1H-indole-2-carboxylic acid [2-(4-piperidin-1-yl-phenyl)-ethyl]-amide
5-Chloro-3-ethyl-1H-indole-2-carboxylic acid [2-(4-piperidin-1-ylphenyl)ethyl]amide

产品登记号

MDL号 MFCD11045300
CAS号 868273-06-7
EC号 278-169-7

产品性质

Empirical Formula (Hill Notation) C24H28ClN3O
纯度 ≥98% (HPLC)
外观 white powder
溶解度 H2O: <2 mg/mL
溶解度 DMSO: >5 mg/mL
MSDS下载 下载链接
个人保护装置 Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
保存温度 2-8°C
德国WGK号 3

产品详细信息

详细说明 (English)
Biochem/physiol Actions
Org 27569 is an allosteric modulator of CB1 cannabinoid receptor. It significantly increases the binding of CB1 receptor agonist [3H]-CP 55,940 (pKB = 5.67) and causes a significant decrease in specific binding of CB1 receptor inverse agonist SR141716A (Rimonabant; pKB = 5.95); in the reporter gene assay behaves as insurmountable CP 55,940 antagonist; pKB = 7.57 at CB1 receptors in mouse vas deferens
详细说明 (简体中文)
Biochem/physiol Actions
Org 27569 is an allosteric modulator of CB1 cannabinoid receptor. It significantly increases the binding of CB1 receptor agonist [3H]-CP 55,940 (pKB = 5.67) and causes a significant decrease in specific binding of CB1 receptor inverse agonist SR141716A (Rimonabant; pKB = 5.95); in the reporter gene assay behaves as insurmountable CP 55,940 antagonist; pKB = 7.57 at CB1 receptors in mouse vas deferens

参考文献