LY-364947

• 产品号: L6293
• CAS号: 396129-53-6
• 分子式: C17H12N4
• 分子量: 272.30398
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: LY-364947
• IUPAC标准名: 4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline
• IUPAC传统名: 4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline
• 别名: HTS 466284; 4-[3-(2-pyridinyl)-1H-pyrazol-4-yl]-quinoline; Transforming Growth Factor-β Type I Receptor Kinase Inhibitor

产品登记号

• PubChem SID: 24724526
• CAS号: 396129-53-6
• MDL号: MFCD00800758

产品性质

• Empirical Formula (Hill Notation): C17H12N4
• 纯度: ≥98% (HPLC)
• 相关基因信息: human ... TGFBR1(7046)
• 外观: tan solid
• 溶解度: H2O: <2 mg/mL
• 溶解度: DMSO: >5 mg/mL
• GHS警示词: Danger
• GHS危险声明: H301-H315-H319-H335-H400
• 欧盟危险性物质标志: 有毒(Toxic) (T)
• 欧盟危险性物质标志: 环境危害性(Nature polluting) (N)
• 个人保护装置: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
• GHS警示性声明: P261-P273-P301 + P310-P305 + P351 + P338
• RID/ADR: UN 2811 6.1/PG 3
• 危险公开号: 25-36/37/38-50/53
• 安全公开号: 26-45-60-61
• 保存温度: 2-8°C
• 联合国危险货物等级: 6.1
• 联合国危险货物编号: 2811
• 联合国危险货物包装类别(PG): 3
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
LY-364947 is a selective, ATP-competitive inhibitor of Transforming Growth Factor-β Type I receptor kinase (TGF-β RI, ALK5) with IC50 = 59 nM. It is much less potent at related kinases, with IC50 = 400 nM for TGF-β RII and IC50 = 1400 nM for mixed lineage kinase-7 (MLK-7), a kinase in the MAP kinase signal pathway and closely related to TGF-β RII. LY-364947 inhibits TGF-β-dependent cellular growth (IC50 = 81 nM) in NIH 3T3 mouse fibroblasts.

详细说明 (简体中文)

Biochem/physiol Actions
LY-364947 is a selective, ATP-competitive inhibitor of Transforming Growth Factor-β Type I receptor kinase (TGF-β RI, ALK5) with IC50 = 59 nM. It is much less potent at related kinases, with IC50 = 400 nM for TGF-β RII and IC50 = 1400 nM for mixed lineage kinase-7 (MLK-7), a kinase in the MAP kinase signal pathway and closely related to TGF-β RII. LY-364947 inhibits TGF-β-dependent cellular growth (IC50 = 81 nM) in NIH 3T3 mouse fibroblasts.