Fumitremorgin C

• 产品号: F9054
• CAS号: 118974-02-0
• 分子式: C22H25N3O3
• 分子量: 379.4522
• 纯 度: >98% (HPLC and TLC)

产品别名

• 标题: Fumitremorgin C
• IUPAC标准名: (1S,12S,15S)-7-methoxy-12-(2-methylprop-1-en-1-yl)-10,13,19-triazapentacyclo[11.7.0.0^3,^1^1.0^4,^9.0^1^5,^1^9]icosa-3(11),4,6,8-tetraene-14,20-dione
• IUPAC传统名: (1S,12S,15S)-7-methoxy-12-(2-methylprop-1-en-1-yl)-10,13,19-triazapentacyclo[11.7.0.0^3,^1^1.0^4,^9.0^1^5,^1^9]icosa-3(11),4,6,8-tetraene-14,20-dione
• 别名: FTC

产品登记号

• CAS号: 118974-02-0
• PubChem SID: 24724486
• MDL号: MFCD08702652

产品性质

• 生物来源: from Neosartorya fischeri
• Empirical Formula (Hill Notation): C22H25N3O3
• 纯度: >98% (HPLC and TLC)
• 运输包装: wet ice
• 外观: film
• 溶解度: acetonitrile: soluble5 mg/mL
• 溶解度: methanol: soluble5 mg/mL
• 溶解度: DMSO: soluble
• 溶解度: chloroform: soluble
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Packaging
Store desiccated at 2-8 °C. Under these conditions, the product is stable for 2 years. A solution in DMSO is stable for 2 months at 2-8 °C.
Biochem/physiol Actions
Fumitremorgin C (FTC) is a fungal toxin of the diketopiperazines family of compounds. In mammalian cells, FTC is tremorgenic and causes cell cycle arrest. Fumitremorgin C has been shown to reverse resistance to doxorubicin, mitoxantrane, and topotecan in non-Pgp (P-glyco-protein), non-MRP (multidrug resistance protein) multidrug-resistance (MDR) cells. This reversal of resistance is associated with an increase in drug accumulation. Fumitremorgin C is a specific, selective, and potent inhibitor at micromolar concentrations of the breast cancer resistant protein (BCRP/ABCG2), an ABC transporter associated with chemotherapy resistance. FTC, in combination with mitoxantrone, can be used for the detection of ABCG2 functional activity in several cell lines.

详细说明 (简体中文)

包装
Store desiccated at 2-8 °C. Under these conditions, the product is stable for 2 years. A solution in DMSO is stable for 2 months at 2-8 °C.
Biochem/physiol Actions
Fumitremorgin C (FTC) is a fungal toxin of the diketopiperazines family of compounds. In mammalian cells, FTC is tremorgenic and causes cell cycle arrest. Fumitremorgin C has been shown to reverse resistance to doxorubicin, mitoxantrane, and topotecan in non-Pgp (P-glyco-protein), non-MRP (multidrug resistance protein) multidrug-resistance (MDR) cells. This reversal of resistance is associated with an increase in drug accumulation. Fumitremorgin C is a specific, selective, and potent inhibitor at micromolar concentrations of the breast cancer resistant protein (BCRP/ABCG2), an ABC transporter associated with chemotherapy resistance. FTC, in combination with mitoxantrone, can be used for the detection of ABCG2 functional activity in several cell lines.