Fenobam

• 产品号: F0430
• CAS号: 57653-26-6
• 分子式: C11H11ClN4O2
• 分子量: 266.68364
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: Fenobam
• IUPAC标准名: 1-(3-chlorophenyl)-3-(1-methyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl)urea
• IUPAC传统名: fenobam
• 别名: N-(3-Chlorophenyl)-N′-(4,5-dihydro-1-methyl-4-oxo-1H-imidazole-2-yl)urea

产品登记号

• CAS号: 57653-26-6
• PubChem SID: 24894721
• MDL号: MFCD00868019

产品性质

• Empirical Formula (Hill Notation): C11H11ClN4O2
• 纯度: ≥98% (HPLC)
• 外观: white solid
• 溶解度: DMSO: >20 mg/mL
• GHS警示词: Danger
• GHS危险声明: H300
• 欧盟危险性物质标志: 有毒(Toxic) (T)
• 个人保护装置: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
• GHS警示性声明: P264-P301 + P310
• RID/ADR: UN 2811 6.1/PG 3
• 危险公开号: 25
• 安全公开号: 45
• 保存温度: 2-8°C
• 联合国危险货物等级: 6.1
• 联合国危险货物编号: 2811
• 联合国危险货物包装类别(PG): 3
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Fenobam is a potent, selective, noncompetitive glutamate mGluR5 receptor antagonist. Fenobam displays inverse agonist properties; blocks mGluR5 constitutive activity in vitro (IC50 = 87 nM, slightly weaker than MPEP). Fenobam acts at an allosteric modulatory site shared with MPEP and binds the mGlu5 receptor with Kd values of 54 and 31 nM for rat and human receptors, respectively. Fenobam belongs to a structurally different class than MPEP; devoid of GABAergic activity and thus typical benzodiazepine-like side effects; displays anxiolytic activity.

详细说明 (简体中文)

Biochem/physiol Actions
Fenobam is a potent, selective, noncompetitive glutamate mGluR5 receptor antagonist. Fenobam displays inverse agonist properties; blocks mGluR5 constitutive activity in vitro (IC50 = 87 nM, slightly weaker than MPEP). Fenobam acts at an allosteric modulatory site shared with MPEP and binds the mGlu5 receptor with Kd values of 54 and 31 nM for rat and human receptors, respectively. Fenobam belongs to a structurally different class than MPEP; devoid of GABAergic activity and thus typical benzodiazepine-like side effects; displays anxiolytic activity.