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Ganaxolone

产品号 G7795 公司名称 Sigma Aldrich
CAS号 38398-32-2 公司网站 http://www.sigmaaldrich.com
分子式 C22H36O2 电 话 1-800-521-8956
分子量 332.52004 传 真
纯 度 (The product is pure based on elemental analysis, NMR, MS, optical rotation and melting point.) 电子邮件
保 存 Chembase数据库ID: 153874

产品价格信息

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产品别名

标题
Ganaxolone
IUPAC标准名
1-[(1S,2S,5R,7S,10R,11S,14S,15S)-5-hydroxy-2,5,15-trimethyltetracyclo[8.7.0.02,7.011,15]heptadecan-14-yl]ethan-1-one
IUPAC传统名
ganaxolone
别名
CCD 1042
3α-Hydroxy-3β-methyl-5α-pregnan-20-one

产品登记号

PubChem SID 24724496
MDL号 MFCD00945298
CAS号 38398-32-2

产品性质

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保存温度 2-8°C
德国WGK号 3
Empirical Formula (Hill Notation) C22H36O2
纯度 (The product is pure based on elemental analysis, NMR, MS, optical rotation and melting point.)
纯度 ≥98% (HPLC)
相关基因信息 human ... GABRA1(2554)mouse ... Gabrg2(14406)
外观 white solid
溶解度 DMSO: ≥2 mg/mL
溶解度 H2O: insoluble

产品详细信息

详细说明 (English)
Biochem/physiol Actions
Ganaxolone (3alpha-hydroxy-3beta-methyl-5alpha-pregnane-20-one) is a positive allosteric modulator of the GABAA receptor subtype; synthetic analog of the endogenous neurosteroid allopregnanolone; effective against chemically induced seizures in rats and mice. Ganaxolone is an orally active analog of allopregnanolone that is not converted to the hormonally active 3-keto form. The enhanced anticonvulsant potency of ganaxolone after neurosteroid withdrawal supports the use of ganaxolone as a specific treatment for perimenstrual catamenial epilepsy.
详细说明 (简体中文)
Biochem/physiol Actions
Ganaxolone (3alpha-hydroxy-3beta-methyl-5alpha-pregnane-20-one) is a positive allosteric modulator of the GABAA receptor subtype; synthetic analog of the endogenous neurosteroid allopregnanolone; effective against chemically induced seizures in rats and mice. Ganaxolone is an orally active analog of allopregnanolone that is not converted to the hormonally active 3-keto form. The enhanced anticonvulsant potency of ganaxolone after neurosteroid withdrawal supports the use of ganaxolone as a specific treatment for perimenstrual catamenial epilepsy.

参考文献