ITSA-1

• 产品号: I4159
• CAS号: 200626-61-5
• 分子式: C13H7Cl2N3O
• 分子量: 292.12018
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: ITSA-1
• IUPAC标准名: 1-(2,4-dichlorobenzoyl)-1H-1,2,3-benzotriazole
• IUPAC传统名: 1-(2,4-dichlorobenzoyl)-1,2,3-benzotriazole
• 别名: N-(1H-Benzotriazol-1-yl)-2,4-dichlorobenzamide; Inhibitor-1 of Trichostatin A; 1-(2,4-Dichlorobenzoyl)-1H-benzotriazole

产品登记号

• CAS号: 200626-61-5
• MDL号: MFCD00195103
• PubChem SID: 24724515

产品性质

• Empirical Formula (Hill Notation): C13H7Cl2N3O
• 纯度: ≥98% (HPLC)
• 外观: solid
• 溶解度: DMSO: ~28 mg/mL
• GHS警示词: Warning
• GHS危险声明: H302
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• 危险公开号: 22
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
ITSA-1 is a suppressor of Trichostatin A (TSA) and a molecular tool for dissecting gene regulation by distinct aceytlation events (histone and tubulin). ITSA-1 is membrane permeable and specifically suppresses TSA inhibition of HDAC (histone deacetylase), but not other HDAC inhibitors. ITSA-1 rreverses TSA induced histone acetylation, overall deacetylation. ITSA-1 also reverses TSA induced cell cycle arrest and apoptosis. Effective range 50 μM.

详细说明 (简体中文)

Biochem/physiol Actions
ITSA-1 is a suppressor of Trichostatin A (TSA) and a molecular tool for dissecting gene regulation by distinct aceytlation events (histone and tubulin). ITSA-1 is membrane permeable and specifically suppresses TSA inhibition of HDAC (histone deacetylase), but not other HDAC inhibitors. ITSA-1 rreverses TSA induced histone acetylation, overall deacetylation. ITSA-1 also reverses TSA induced cell cycle arrest and apoptosis. Effective range 50 μM.