N-(4-Bromophenyl)-3-[[(4-bromophenyl)amino]sulfonyl]benzamide

• 产品号: B3436
• CAS号: 300670-16-0
• 分子式: C19H14Br2N2O3S
• 分子量: 510.19906
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: N-(4-Bromophenyl)-3-[[(4-bromophenyl)amino]sulfonyl]benzamide
• IUPAC标准名: N-(4-bromophenyl)-3-[(4-bromophenyl)sulfamoyl]benzamide
• IUPAC传统名: N-(4-bromophenyl)-3-[(4-bromophenyl)sulfamoyl]benzamide
• 别名: C2-8

产品登记号

• CAS号: 300670-16-0
• MDL号: MFCD00355835
• PubChem SID: 24724418

产品性质

• Empirical Formula (Hill Notation): C19H14Br2N2O3S
• 纯度: ≥98% (HPLC)
• 外观: off-white solid
• 溶解度: DMSO: ~20 mg/mL
• 溶解度: H2O: insoluble
• GHS警示词: Warning
• GHS危险声明: H319-H413
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves
• GHS警示性声明: P305 + P351 + P338
• 危险公开号: 36
• 安全公开号: 26
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
N-(4-Bromophenyl)-3-[[(4-bromophenyl)amino]sulfonyl]benzamide is the first inhibitor of aggregation of the polyglutamine (polyQ) sequence of the Huntington′s Disease protein (huntingtin); polyQ aggregation is neurotoxic, and inhibitors of aggregation may be therapeutic in HD and other polyQ diseases; C2-8 inhibited aggregation in HD PC12 cells with an IC50 of 50nM; when administered in food, suppressed neurodegeneration in vivo in the Drosophila HD model.

详细说明 (简体中文)

Biochem/physiol Actions
N-(4-Bromophenyl)-3-[[(4-bromophenyl)amino]sulfonyl]benzamide is the first inhibitor of aggregation of the polyglutamine (polyQ) sequence of the Huntington′s Disease protein (huntingtin); polyQ aggregation is neurotoxic, and inhibitors of aggregation may be therapeutic in HD and other polyQ diseases; C2-8 inhibited aggregation in HD PC12 cells with an IC50 of 50nM; when administered in food, suppressed neurodegeneration in vivo in the Drosophila HD model.