Aurothioglucose hydrate

• 产品号: A0606
• CAS号: 12192-57-3(anhydrous)
• 分子式: C6H13AuO6S
• 分子量: 410.19537
• 纯 度: ≥97% (titration)
• 保 存: desiccated

产品别名

• 标题: Aurothioglucose hydrate
• IUPAC标准名: (2R,3R,4S,5S,6R)-2-(auriosulfanyl)-6-(hydroxymethyl)oxane-3,4,5-triol hydrate
• IUPAC传统名: aurothioglucose hydrate
• 别名: Solganol; Solganal; Gold thioglucose

产品登记号

• PubChem SID: 24724383
• CAS号: 12192-57-3(anhydrous)
• EC号: 235-365-7

产品性质

• Empirical Formula (Hill Notation): C6H11AuO5S · xH2O
• 纯度: ≥97% (titration)
• 外观: off-white powder
• 溶解度: H2O: >5 mg/mL
• GHS警示词: Danger
• GHS危险声明: H317-H334
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• GHS警示性声明: P261-P280-P342 + P311
• 危险公开号: 42/43
• 安全公开号: 22-36/37-45
• 保存条件: desiccated
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Aurothioglucose, a gold compound used clinically to treat rheumatoid arthritis, has recently been found to be a potent PKCiota-Par6 interaction inhibitor, with an IC50 approximately 1 μM. Disruption of this interaction disrupts a rac1 signaling pathway that is required for transformed growth in non-small-cell lung cancer.

详细说明 (简体中文)

Biochem/physiol Actions
Aurothioglucose, a gold compound used clinically to treat rheumatoid arthritis, has recently been found to be a potent PKCiota-Par6 interaction inhibitor, with an IC50 approximately 1 μM. Disruption of this interaction disrupts a rac1 signaling pathway that is required for transformed growth in non-small-cell lung cancer.