Pifithrin-μ

• 产品号: P0122
• CAS号: 64984-31-2
• 分子式: C8H7NO2S
• 分子量: 181.21168
• 纯 度: ≥97% (HPLC)
• 保 存: desiccated

产品别名

• 标题: Pifithrin-μ
• IUPAC标准名: phenylethynesulfonamide
• IUPAC传统名: phenylethynesulfonamide
• 别名: PFTμ; PFT-μ; 2-Phenyl-ethynesulfoanide; 2-Phenylethynesulfonamide

产品登记号

• MDL号: MFCD00181531
• PubChem SID: 24724568
• CAS号: 64984-31-2

产品性质

• Empirical Formula (Hill Notation): C8H7NO2S
• 纯度: ≥97% (HPLC)
• 外观: solid
• 溶解度: DMSO: >10 mg/mL
• 溶解度: H2O: <2 mg/mL
• GHS警示词: Warning
• GHS危险声明: H302-H315-H319-H335
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves
• GHS警示性声明: P261-P305 + P351 + P338
• 危险公开号: 22-36/37/38
• 安全公开号: 26
• 保存条件: desiccated
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Pifithrin-μ is an inhibitor of p53 binding and anti-apoptotic, which directly inhibits p53 binding to mitochondria as well as to Bcl-xL and Bcl-2 proteins. PFTμ rescues cells from lethal γ-irradiation-induced cell death. Because pifithrin-μ shuts down only the p53-mitochondrial pathway without affecting the transcriptional functions of p53, it is superior to pifithrin-α.

详细说明 (简体中文)

Biochem/physiol Actions
Pifithrin-μ is an inhibitor of p53 binding and anti-apoptotic, which directly inhibits p53 binding to mitochondria as well as to Bcl-xL and Bcl-2 proteins. PFTμ rescues cells from lethal γ-irradiation-induced cell death. Because pifithrin-μ shuts down only the p53-mitochondrial pathway without affecting the transcriptional functions of p53, it is superior to pifithrin-α.