您当前所在的位置:首页 > 产品中心 > 产品信息
Phenserine_分子结构_CAS_101246-66-6)
点击图片或这里关闭

Phenserine

产品号 P0111 公司名称 Sigma Aldrich
CAS号 101246-66-6 公司网站 http://www.sigmaaldrich.com
分子式 C20H23N3O2 电 话 1-800-521-8956
分子量 337.41552 传 真
纯 度 ≥98% (HPLC) 电子邮件
保 存 Chembase数据库ID: 153858

产品价格信息

请登录

产品别名

标题
Phenserine
IUPAC标准名
(3aS,8aR)-1,3a,8-trimethyl-1H,2H,3H,3aH,8H,8aH-pyrrolo[2,3-b]indol-5-yl N-phenylcarbamate
IUPAC传统名
(3aS,8aR)-1,3a,8-trimethyl-2H,3H,8aH-pyrrolo[2,3-b]indol-5-yl N-phenylcarbamate
别名
1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-pyrrolo[2,3-b]indol-5-ol phenylcarbamate (ester)
(-)-N-Phenylcarbamoyleseroline

产品登记号

CAS号 101246-66-6
MDL号 MFCD00672748

产品性质

Empirical Formula (Hill Notation) C20H23N3O2
纯度 ≥98% (HPLC)
外观 off-white solid
溶解度 H2O: <2 mg/mL
溶解度 DMSO: >5 mg/mL
GHS危险品标识 GHS07
GHS警示词 Warning
GHS危险声明 H315-H319-H335
欧盟危险性物质标志 刺激性(Irritant) 刺激性(Irritant) (Xi)
MSDS下载 下载链接
个人保护装置 dust mask type N95 (US), Eyeshields, Gloves
GHS警示性声明 P261-P305 + P351 + P338
危险公开号 36/37/38
RTECS编号 UY8586000
安全公开号 26
保存温度 2-8°C
德国WGK号 3

产品详细信息

详细说明 (English)
Biochem/physiol Actions
(-)-Phenserine, a phenylcarbamate derivative, is a selective, non-competitive inhibitor of acetylcholinesterase (AChE). (-)-Phenserine produces rapid, potent, and long-lasting AChE inhibition, in vivo. It is significantly less toxic than (-)-physostigmine. (-)-Phenserine improves cognitive performance in both young learning-impaired and elderly rats. Reduced secretion of β-amyloid (Abeta) has been observed in cell lines exposed to (-)-phenserine, occurring through translational regulation of β-amyloid precursor protein (beta-APP) mRNA via a non-cholinergic mechanism. These in vitro findings appear to translate in vivo into animal models and humans.
详细说明 (简体中文)
Biochem/physiol Actions
(-)-Phenserine, a phenylcarbamate derivative, is a selective, non-competitive inhibitor of acetylcholinesterase (AChE). (-)-Phenserine produces rapid, potent, and long-lasting AChE inhibition, in vivo. It is significantly less toxic than (-)-physostigmine. (-)-Phenserine improves cognitive performance in both young learning-impaired and elderly rats. Reduced secretion of β-amyloid (Abeta) has been observed in cell lines exposed to (-)-phenserine, occurring through translational regulation of β-amyloid precursor protein (beta-APP) mRNA via a non-cholinergic mechanism. These in vitro findings appear to translate in vivo into animal models and humans.

参考文献