NIDA-41020

• 产品号: N8162
• CAS号: 502486-89-7
• 分子式: C23H24Cl2N4O2
• 分子量: 459.36826
• 纯 度: ≥97% (HPLC)

产品别名

• 标题: NIDA-41020
• IUPAC标准名: 1-(2,4-dichlorophenyl)-5-(4-methoxyphenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide
• IUPAC传统名: 1-(2,4-dichlorophenyl)-5-(4-methoxyphenyl)-4-methyl-N-(piperidin-1-yl)pyrazole-3-carboxamide
• 别名: 1-(2,4-Dichlorophenyl)-5-(4-methoxyphenyl)-4-methyl-N-(1-piperidinyl)-1H-pyrazole-3-carboxamide

产品登记号

• CAS号: 502486-89-7
• MDL号: MFCD08277026

产品性质

• 联合国危险货物编号: 2811
• 联合国危险货物包装类别(PG): 3
• 德国WGK号: 3
• GHS警示词: Danger
• GHS危险声明: H300-H315-H319-H335
• 欧盟危险性物质标志: 有毒(Toxic) (T)
• 个人保护装置: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
• GHS警示性声明: P261-P264-P301 + P310-P305 + P351 + P338
• RID/ADR: UN 2811 6.1/PG 3
• 危险公开号: 25-36/37/38
• 安全公开号: 26-45
• 保存温度: 2-8°C
• 联合国危险货物等级: 6.1
• Empirical Formula (Hill Notation): C23H24Cl2N4O2
• 纯度: ≥97% (HPLC)
• 外观: off-white solid
• 溶解度: DMSO: ~16 mg/mL
• 溶解度: H2O: insoluble

产品详细信息

详细说明 (English)

Biochem/physiol Actions
NIDA-41020 is a CB1 cannabinoid receptor antagonist. NIDA-41020 is structurally similar to Rimonabant, which is currently in clinical development. NIDA-41020 is less lipophilic; developed at NIDA as a potential radioligand for CB1 receptors, Ki = 4.1 nM [in comparison AM 251, AM 281, SR 141716 (Rimonabant) have Ki of 0.6, 4.5 and 1.8 nM respectively].

详细说明 (简体中文)

Biochem/physiol Actions
NIDA-41020 is a CB1 cannabinoid receptor antagonist. NIDA-41020 is structurally similar to Rimonabant, which is currently in clinical development. NIDA-41020 is less lipophilic; developed at NIDA as a potential radioligand for CB1 receptors, Ki = 4.1 nM [in comparison AM 251, AM 281, SR 141716 (Rimonabant) have Ki of 0.6, 4.5 and 1.8 nM respectively].