5-(2-Benzothiazolyl)-3-ethyl-2-[2-(methylphenylamino)ethenyl]-1-phenyl-1H-benzimidazolium iodide

• 产品号: B2311
• CAS号: 681281-88-9
• 分子式: C31H27IN4S
• 分子量: 614.54235
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: 5-(2-Benzothiazolyl)-3-ethyl-2-[2-(methylphenylamino)ethenyl]-1-phenyl-1H-benzimidazolium iodide
• IUPAC标准名: 5-(1,3-benzothiazol-2-yl)-3-ethyl-2-{2-[methyl(phenyl)amino]ethenyl}-1-phenyl-1H-1,3-benzodiazol-3-ium iodide
• IUPAC传统名: 6-(1,3-benzothiazol-2-yl)-1-ethyl-2-{2-[methyl(phenyl)amino]ethenyl}-3-phenyl-1,3-benzodiazol-1-ium iodide

产品登记号

• CAS号: 681281-88-9
• PubChem SID: 24724416
• MDL号: MFCD00570739

产品性质

• Empirical Formula (Hill Notation): C31H27IN4S
• 纯度: ≥98% (HPLC)
• 外观: orange solid
• 溶解度: DMSO: ≥10 mg/mL
• GHS警示词: Warning
• GHS危险声明: H315-H319-H335
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves
• GHS警示性声明: P261-P305 + P351 + P338
• 危险公开号: 36/37/38
• 安全公开号: 26-36
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
5-(2-Benzothiazolyl)-3-ethyl-2-[2-(methylphenylamino)-ethenyl]-1-phenyl-1H-benzimidazolium or Akt Inhibitor IV is a cell-permeable benzimidazole compound that inhibits Akt phosphorylation/activation by targeting the ATP binding site of a kinase upstream of Akt, but downstream of PI3K. Shown to block Akt-mediated FOXO1a nuclear export (IC₅₀ = 0.625μM) and cell proliferation (IC₅₀ < 1.25μM) in 786-O cells. Unlike phosphatidylinositol analog-based Akt inhibitors, this inhibitor does not affect PI3K.

详细说明 (简体中文)

Biochem/physiol Actions
5-(2-Benzothiazolyl)-3-ethyl-2-[2-(methylphenylamino)-ethenyl]-1-phenyl-1H-benzimidazolium or Akt Inhibitor IV is a cell-permeable benzimidazole compound that inhibits Akt phosphorylation/activation by targeting the ATP binding site of a kinase upstream of Akt, but downstream of PI3K. Shown to block Akt-mediated FOXO1a nuclear export (IC₅₀ = 0.625μM) and cell proliferation (IC₅₀ < 1.25μM) in 786-O cells. Unlike phosphatidylinositol analog-based Akt inhibitors, this inhibitor does not affect PI3K.