Ionomycin caicium salt 钙盐

• 产品号: I3909
• 分子式: C41H70CaO9
• 分子量: 747.0671
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: Ionomycin calcium salt
• IUPAC标准名: (7R,9S,11S)-14-[(2R,4R,8R,9R,10S,11S)-9,11-dihydroxy-12-[(2S,5S)-5-[(2R,5S)-5-[(1R)-1-hydroxyethyl]-5-methyloxolan-2-yl]-5-methyloxolan-2-yl]-4,8,10-trimethyldodec-6-en-2-yl]-7,9,11-trimethyl-1,3-dioxa-2-calcacyclotetradec-13-ene-4,12-dione
• IUPAC传统名: (7R,9S,11S)-14-[(2R,4R,8R,9R,10S,11S)-9,11-dihydroxy-12-[(2S,5S)-5-[(2R,5S)-5-[(1R)-1-hydroxyethyl]-5-methyloxolan-2-yl]-5-methyloxolan-2-yl]-4,8,10-trimethyldodec-6-en-2-yl]-7,9,11-trimethyl-1,3-dioxa-2-calcacyclotetradec-13-ene-4,12-dione

产品登记号

• EC号: 200-664-3
• MDL号: MFCD00083634

产品性质

• 生物来源: from Streptomyces conglobatus
• 浓度: 1 mM in DMSO
• Empirical Formula (Hill Notation): C41H70CaO9
• 纯度: ≥98% (HPLC)
• 产品质量级别: PREMIUM
• 运输包装: wet ice
• 无菌消毒: 0.2 μm filtered
• 闪点: 87 °C
• 闪点: 188.6 °F
• 个人保护装置: Eyeshields, Gloves, half-mask respirator (US), multi-purpose combination respirator cartridge (US)
• 保存温度: -20°C
• 德国WGK号: 1

产品详细信息

详细说明 (English)

Frequently Asked Questions
Live Chat and Frequently Asked Questions are available for this Product.
Application
Ionomycin is an ionophore produced by the bacterium Streptomyces conglobatus. It has been shown to induce central demyelination 1, inhibit adrenal bovine TREK-1 channels 2, and to regulate cell division of mature human B cells 3. It is used to study the effects of calcium flux on endoplasmic reticulum (ER) stress, mitochodrial stress and intrinsic apoptosis mechanisms. It is also used to stimulate the intracellular production of the cytokines, interferon, perforin, IL-2, and IL-4 usually in conjunction with PMA. Product I3909 is a Ready Made Solution, from Streptomyces conglobatus. The concentration is 1 Mm in DMSO and it is 0.2 μm filtered.
Biochem/physiol Actions
Ca2+ ionophore that is more effective than A23187 as a mobile ion carrier for Ca2+; non-fluorescent; used to study Ca2+ transport across biological membranes; induces apoptotic degeneration of embryonic cortical neurons.
Ionomycin is a Ca2+ ionophore that is more effective than A23187 as a mobile ion carrier for Ca2+. It is non-fluorescent. It induces apoptotic degeneration of embryonic cortical neurons, induces central demyelination 1 and inhibits adrenal bovine TREK-1 channels2.
Protocols & Applications
Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information

详细说明 (简体中文)

Frequently Asked Questions
Live Chat and Frequently Asked Questions are available for this Product.
Application
Ionomycin is an ionophore produced by the bacterium Streptomyces conglobatus. It has been shown to induce central demyelination 1, inhibit adrenal bovine TREK-1 channels 2, and to regulate cell division of mature human B cells 3. It is used to study the effects of calcium flux on endoplasmic reticulum (ER) stress, mitochodrial stress and intrinsic apoptosis mechanisms. It is also used to stimulate the intracellular production of the cytokines, interferon, perforin, IL-2, and IL-4 usually in conjunction with PMA. Product I3909 is a Ready Made Solution, from Streptomyces conglobatus. The concentration is 1 Mm in DMSO and it is 0.2 μm filtered.
Biochem/physiol Actions
Ca2+ ionophore that is more effective than A23187 as a mobile ion carrier for Ca2+; non-fluorescent; used to study Ca2+ transport across biological membranes; induces apoptotic degeneration of embryonic cortical neurons.
Ionomycin is a Ca2+ ionophore that is more effective than A23187 as a mobile ion carrier for Ca2+. It is non-fluorescent. It induces apoptotic degeneration of embryonic cortical neurons, induces central demyelination 1 and inhibits adrenal bovine TREK-1 channels2.
Protocols & Applications
Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information