Nα-Methylhistamine dihydrochloride

• 产品号: H5914
• CAS号: 16503-22-3
• 分子式: C6H13Cl2N3
• 分子量: 198.09352
• 纯 度: (The product is pure based on elemental analysis results, NMR and MS spectra.)

产品别名

• 标题: Nα-Methylhistamine dihydrochloride
• IUPAC标准名: [2-(1H-imidazol-4-yl)ethyl](methyl)amine dihydrochloride
• IUPAC传统名: [2-(1H-imidazol-4-yl)ethyl](methyl)amine dihydrochloride
• 别名: NAMH dihydrochloride; N-Methyl-1H-imidazole-4-ethanamine dihydrochloride

产品登记号

• CAS号: 16503-22-3
• PubChem SID: 24724503
• MDL号: MFCD00134838

产品性质

• Empirical Formula (Hill Notation): C6H11N3 · 2HCl
• 纯度: (The product is pure based on elemental analysis results, NMR and MS spectra.)
• 外观: white solid
• 溶解度: H2O: >20 mg/mL
• GHS警示词: Danger
• GHS危险声明: H302-H315-H318-H335
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves
• GHS警示性声明: P261-P280-P305 + P351 + P338
• 危险公开号: 22-37/38-41
• 安全公开号: 26-36/37/39
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Production of N-alpha-methyl-histamine (NAMH), a histamine H(3) receptor (H3R) agonist, is promoted in Helicobacter pylori infected human gastric mucosa. NAMH acts directly on histamine H(2) receptors (H2Rs) in animals to stimulate acid secretion and to be a H2R agonist. NAMH dose dependently stimulated cAMP productions in CHO-H2R cells. This production was inhibited by famotidine but not by thioperamide. Control CHO cells were unresponsive to either histamine or NAMH. In addition, the effect of NAMH, in terms of cAMP production in CHO-H2R cells, was more potent than that of histamine-that is, with a lower EC50 concentration and higher maximal cAMP production. Both NAMH and histamine, but not R-alpha-methyl-histamine, effectively inhibited [(3)H] tiotidine binding to CHO-H2R cells. These results confirm that NAMH, which is produced in the gastric mucosa by H pylori, is a potent H2R agonist as well as a H3R agonist.

详细说明 (简体中文)

Biochem/physiol Actions
Production of N-alpha-methyl-histamine (NAMH), a histamine H(3) receptor (H3R) agonist, is promoted in Helicobacter pylori infected human gastric mucosa. NAMH acts directly on histamine H(2) receptors (H2Rs) in animals to stimulate acid secretion and to be a H2R agonist. NAMH dose dependently stimulated cAMP productions in CHO-H2R cells. This production was inhibited by famotidine but not by thioperamide. Control CHO cells were unresponsive to either histamine or NAMH. In addition, the effect of NAMH, in terms of cAMP production in CHO-H2R cells, was more potent than that of histamine-that is, with a lower EC50 concentration and higher maximal cAMP production. Both NAMH and histamine, but not R-alpha-methyl-histamine, effectively inhibited [(3)H] tiotidine binding to CHO-H2R cells. These results confirm that NAMH, which is produced in the gastric mucosa by H pylori, is a potent H2R agonist as well as a H3R agonist.