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GW3965 hydrochloride_分子结构_CAS_405911-17-3)
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GW3965 hydrochloride

产品号 G6295 公司名称 Sigma Aldrich
CAS号 405911-17-3 公司网站 http://www.sigmaaldrich.com
分子式 C33H32Cl2F3NO3 电 话 1-800-521-8956
分子量 618.5132896 传 真
纯 度 ≥98% (HPLC) 电子邮件
保 存 Chembase数据库ID: 73112

产品价格信息

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产品别名

标题
GW3965 hydrochloride
IUPAC标准名
2-{3-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2,2-diphenylethyl)amino)propoxy]phenyl}acetic acid hydrochloride
IUPAC传统名
C33H31ClF3NO3 hydrochloride
别名
3-[3-[N-(2-Chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyloxy]phenylacetic acid hydrochloride

产品登记号

PubChem SID 24724494
CAS号 405911-17-3
MDL号 MFCD08276920

产品性质

Empirical Formula (Hill Notation) C33H31F3ClNO3 · HCl
纯度 ≥98% (HPLC)
外观 white powder
溶解度 DMSO: ≥20 mg/mL
GHS危险品标识 GHS05
GHS危险品标识 GHS07
GHS警示词 Danger
GHS危险声明 H302-H318-H413
欧盟危险性物质标志 有害性(Harmful) 有害性(Harmful) (Xn)
MSDS下载 下载链接
个人保护装置 dust mask type N95 (US), Eyeshields, Gloves
GHS警示性声明 P280-P305 + P351 + P338
危险公开号 22-41
安全公开号 26-39
德国WGK号 3

产品详细信息

详细说明 (English)
Biochem/physiol Actions
GW3965 is a liver X receptor full agonist on hLXRα and hLXRβ. GW3965 has an EC50 = 125 nM in a cell-free ligand-sensing assay of LXRα and profiles as a full agonist on hLXRα and hLXRβ in cell-based assays with EC50 = 190 nM and 30 nM, respectively. It is orally active in mice. When screened against a panel of nuclear receptors, it cross-reacted with only the pregnane X receptor (PXR). The literature agonist, T0901317 (Tularik), had an EC50 = 60 nM and 85 nM in the cell-free and cell-based assays, respectively.
详细说明 (简体中文)
Biochem/physiol Actions
GW3965 is a liver X receptor full agonist on hLXRα and hLXRβ. GW3965 has an EC50 = 125 nM in a cell-free ligand-sensing assay of LXRα and profiles as a full agonist on hLXRα and hLXRβ in cell-based assays with EC50 = 190 nM and 30 nM, respectively. It is orally active in mice. When screened against a panel of nuclear receptors, it cross-reacted with only the pregnane X receptor (PXR). The literature agonist, T0901317 (Tularik), had an EC50 = 60 nM and 85 nM in the cell-free and cell-based assays, respectively.

参考文献