Ionomycin from Streptomyces conglobatus

• 产品号: I9657
• CAS号: 56092-81-0
• 分子式: C41H72O9
• 分子量: 709.00498
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: Ionomycin from Streptomyces conglobatus
• IUPAC标准名: (4R,6S,8S,12R,14R,18R,19R,20S,21S)-11,19,21-trihydroxy-22-[(2S,5S)-5-[(2R,5S)-5-[(1R)-1-hydroxyethyl]-5-methyloxolan-2-yl]-5-methyloxolan-2-yl]-4,6,8,12,14,18,20-heptamethyl-9-oxodocosa-10,16-dienoic acid
• IUPAC传统名: (4R,6S,8S,12R,14R,18R,19R,20S,21S)-11,19,21-trihydroxy-22-[(2S,5S)-5-[(2R,5S)-5-[(1R)-1-hydroxyethyl]-5-methyloxolan-2-yl]-5-methyloxolan-2-yl]-4,6,8,12,14,18,20-heptamethyl-9-oxodocosa-10,16-dienoic acid

产品登记号

• MDL号: MFCD06798385
• Beilstein号: 3642126
• CAS号: 56092-81-0
• PubChem SID: 24896159

产品性质

• Empirical Formula (Hill Notation): C41H72O9
• 纯度: ≥98% (HPLC)
• 产品质量级别: PREMIUM
• GHS警示词: Warning
• GHS危险声明: H302
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves
• 危险公开号: 22
• RTECS编号: NO0600000
• 安全公开号: 36
• 保存温度: -20°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Application
Ionomycin is an ionophore produced by the bacterium Streptomyces conglobatus. It has been shown to induce central demyelination , inhibit adrenal bovine TREK-1 channels , and to regulate cell division of mature human B cells . It is used to study the effects of calcium flux on endoplasmic reticulum (ER) stress, mitochodrial stress and intrinsic apoptosis mechanisms. It is also used to stimulate the intracellular production of the cytokines, interferon, perforin, IL-2, and IL-4 usually in conjunction with PMA.
Biochem/physiol Actions
Ionomycin is a Ca2+ ionophore that is more effective than A23187 as a mobile ion carrier for Ca2+. It is non-fluorescent. It induces apoptotic degeneration of embryonic cortical neurons, induces central demyelination and inhibits adrenal bovine TREK-1 channels.
Protocols & Applications
Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information

详细说明 (简体中文)

Application
Ionomycin is an ionophore produced by the bacterium Streptomyces conglobatus. It has been shown to induce central demyelination , inhibit adrenal bovine TREK-1 channels , and to regulate cell division of mature human B cells . It is used to study the effects of calcium flux on endoplasmic reticulum (ER) stress, mitochodrial stress and intrinsic apoptosis mechanisms. It is also used to stimulate the intracellular production of the cytokines, interferon, perforin, IL-2, and IL-4 usually in conjunction with PMA.
Biochem/physiol Actions
Ionomycin is a Ca2+ ionophore that is more effective than A23187 as a mobile ion carrier for Ca2+. It is non-fluorescent. It induces apoptotic degeneration of embryonic cortical neurons, induces central demyelination and inhibits adrenal bovine TREK-1 channels.
Protocols & Applications
Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information