Biochem/physiol Actions Cycloheximide (CHX) is an antibiotic produced by S. griseus that inhibits protein biosynthesis in eukaryotes. Its main biological activity is translation inhibition which results in cell growth arrest and cell death. Cycloheximide (CHX) is an antibiotic produced by S. griseus. Its main biological activity is translation inhibition in eukaryotes resulting in cell growth arrest and cell death. CHX is widely used for selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors. Application CHX is widely used for selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors. It has been shown to selectively clear macrophages in atherosclerotic plaques 1 and activate cumulus-free equine oocytes 2. Protocols & Applications Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information |
Biochem/physiol Actions Cycloheximide (CHX) is an antibiotic produced by S. griseus that inhibits protein biosynthesis in eukaryotes. Its main biological activity is translation inhibition which results in cell growth arrest and cell death. 放线菌酮 (CHX) 是由灰色链霉菌产生的抗生素。它的主要生物活性为真核生物中的翻译抑制,从而导致细胞生长停滞和细胞死亡。CHX 广泛用于选择酵母菌和真菌 CHX 耐药株,可控抑制蛋白合成以检测短寿命蛋白和超高诱导蛋白表达,以及进行凋亡诱导或通过死亡受体促进凋亡诱导。 Application CHX is widely used for selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors. It has been shown to selectively clear macrophages in atherosclerotic plaques 1 and activate cumulus-free equine oocytes 2. Protocols & Applications Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information |