Fibrinogen-binding Inhibitor Peptide

• 产品号: F9145
• CAS号: 89105-94-2
• 分子式: C50H80N18O16
• 分子量: 1189.2812
• 纯 度: ≥97% (HPLC)

产品别名

• 标题: Fibrinogen-binding Inhibitor Peptide
• IUPAC标准名: (2S)-2-[(2S)-2-{2-[(2S)-2-[(2S)-2-[(2S)-6-amino-2-[(2S)-2-(2-{2-[(2S)-2-[(2S)-2-[(2S)-2-amino-3-(1H-imidazol-4-yl)propanamido]-3-(1H-imidazol-4-yl)propanamido]-4-methylpentanamido]acetamido}acetamido)propanamido]hexanamido]-4-carbamoylbutanamido]propanamido]acetamido}-3-carboxypropanamido]-3-methylbutanoic acid
• IUPAC传统名: (2S)-2-[(2S)-2-{2-[(2S)-2-[(2S)-2-[(2S)-6-amino-2-[(2S)-2-(2-{2-[(2S)-2-[(2S)-2-[(2S)-2-amino-3-(1H-imidazol-4-yl)propanamido]-3-(1H-imidazol-4-yl)propanamido]-4-methylpentanamido]acetamido}acetamido)propanamido]hexanamido]-4-carbamoylbutanamido]propanamido]acetamido}-3-carboxypropanamido]-3-methylbutanoic acid
• 别名: Fibrinogen-γ Fragment 400-411

产品登记号

• CAS号: 89105-94-2
• MDL号: MFCD00167528

产品性质

• 主要成分: Peptide content, ~70%
• Empirical Formula (Hill Notation): C50H80N18O16
• 纯度: ≥97% (HPLC)
• 相关基因信息: human ... FGG(2266)
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• 保存温度: -20°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Amino Acid Sequence
His-His-Leu-Gly-Gly-Ala-Lys-Gln-Ala-Gly-Asp-Val
Biochem/physiol Actions
Fibrinogen γ 400-411, a non-RGD containing sequence, is derived from plasmin digestion. If platelet activation is blocked with prostaglandin E1 blockade, it is required for the establishment of initial contact and support spreading but not firm adhesion on immobilized substrate. However, in activated platelets, single γ 400-411 sequence is no longer required for initiation of adhesion but becomes sufficient for firm adhesion. In contrast to the binding of whole fibrinogen, binding of fragment 400-411 does not lead to tyrosine phosphorylation for platelet proteins.

详细说明 (简体中文)

Amino Acid Sequence
His-His-Leu-Gly-Gly-Ala-Lys-Gln-Ala-Gly-Asp-Val
Biochem/physiol Actions
Fibrinogen γ 400-411, a non-RGD containing sequence, is derived from plasmin digestion. If platelet activation is blocked with prostaglandin E1 blockade, it is required for the establishment of initial contact and support spreading but not firm adhesion on immobilized substrate. However, in activated platelets, single γ 400-411 sequence is no longer required for initiation of adhesion but becomes sufficient for firm adhesion. In contrast to the binding of whole fibrinogen, binding of fragment 400-411 does not lead to tyrosine phosphorylation for platelet proteins.