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Paclitaxel

产品号 T1912 公司名称 Sigma Aldrich
CAS号 33069-62-4 公司网站 http://www.sigmaaldrich.com
分子式 C47H51NO14 电 话 1-800-521-8956
分子量 853.90614 传 真
纯 度 电子邮件
保 存 Chembase数据库ID: 137569

产品价格信息

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产品别名

标题
Paclitaxel
IUPAC标准名
(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-bis(acetyloxy)-1,9-dihydroxy-15-{[(2R,3S)-2-hydroxy-3-phenyl-3-(phenylformamido)propanoyl]oxy}-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl benzoate
IUPAC传统名
taxol

产品登记号

MDL号 MFCD00869953
CAS号 33069-62-4
PubChem SID 24899998
Beilstein号 1420457

产品性质

生物来源 from Taxus yannanensis
Empirical Formula (Hill Notation) C47H51NO14
相关基因信息 human ... BCL2(596)
外观 white powder
熔点 213 °C (dec.)(lit.)
溶解度 DMSO: soluble50 mg/mL (can be stored frozen for several months)
溶解度 ethanol: soluble
溶解度 methanol: soluble (undergoes transesterification)
GHS危险品标识 GHS05
GHS危险品标识 GHS07
GHS危险品标识 GHS08
GHS警示词 Danger
GHS危险声明 H315-H317-H318-H334-H335-H341-H361
欧盟危险性物质标志 有害性(Harmful) 有害性(Harmful) (Xn)
MSDS下载 下载链接
个人保护装置 Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
GHS警示性声明 P261-P280-P305 + P351 + P338-P342 + P311
危险公开号 37/38-41-42/43-62-68
RTECS编号 DA8340700
安全公开号 22-26-36/37/39-45
保存温度 2-8°C
德国WGK号 3

产品详细信息

详细说明 (English)
Caution
Paclitaxel undergoes transesterification in methanol and hydrolyzes in aqueous solutions.
Biochem/physiol Actions
Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase. The microtubule damage induces apoptosis through a JNK-dependent pathway followed by a JNK-independent pathway, perhaps related to the activation of protein kinase A (PKA) or of Raf-1 kinase, resulting in phosphorylation of Bcl-2. A major metabolite via CYP2CB is 6α-hydroxypaclitaxel (6α-OHP).
详细说明 (简体中文)
Caution
Paclitaxel undergoes transesterification in methanol and hydrolyzes in aqueous solutions.
Biochem/physiol Actions
Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase. The microtubule damage induces apoptosis through a JNK-dependent pathway followed by a JNK-independent pathway, perhaps related to the activation of protein kinase A (PKA) or of Raf-1 kinase, resulting in phosphorylation of Bcl-2. A major metabolite via CYP2CB is 6α-hydroxypaclitaxel (6α-OHP).

参考文献