iCRT14

• 产品号: SML0203
• CAS号: 677331-12-3
• 分子式: C21H17N3O2S
• 分子量: 375.44358
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: iCRT14
• IUPAC标准名: 5-{[2,5-dimethyl-1-(pyridin-3-yl)-1H-pyrrol-3-yl]methylidene}-3-phenyl-1,3-thiazolidine-2,4-dione
• IUPAC传统名: 5-{[2,5-dimethyl-1-(pyridin-3-yl)pyrrol-3-yl]methylidene}-3-phenyl-1,3-thiazolidine-2,4-dione
• 别名: 5-[[2,5-Dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]methylene]-3-phenyl-2,4-thiazolidinedione

产品登记号

• MDL号: MFCD04366833
• CAS号: 677331-12-3

产品性质

• Empirical Formula (Hill Notation): C21H17N3O2S
• 纯度: ≥98% (HPLC)
• 外观: yellow to orange powder
• 溶解度: DMSO: ≥10 mg/mL
• 保存温度: 2-8°C

产品详细信息

详细说明 (简体中文)

Biochem/physiol Actions
iCRT14 is a Wnt / β-catenin pathway inhibitor. It is a potent inhibitor of Catenin Responsive Transcription (CRT) reporter genes, as well as endogenous gene targets. iCRT14 also disrupts β-catenin-TCF4 interaction in a dose dependent manner, and causes G0/G1 arrest in colon tumor lines.