S 17092

• 产品号: SML0181
• CAS号: 176797-26-5
• 分子式: C22H28N2O2S
• 分子量: 384.53492
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: S 17092
• IUPAC标准名: (2S,3aS,7aS)-1-[(1R,2R)-2-phenylcyclopropanecarbonyl]-2-(1,3-thiazolidine-3-carbonyl)-octahydro-1H-indole
• IUPAC传统名: (2S,3aS,7aS)-1-[(1R,2R)-2-phenylcyclopropanecarbonyl]-2-(1,3-thiazolidine-3-carbonyl)-octahydroindole
• 别名: (2S,3aS,7aS)-1-(((R,R)-2-Phenylcyclopropyl)carbonyl)-2-((thiazolidin-3-yl)carbonyl)octahydro-1H-indole; [(2S,3aS,7aS)-Octahydro-1-[[(1R,2R)-2-phenylcyclopropyl]carbonyl]-1H-indol-2-yl]-3-thiazolidinyl--methanone

产品登记号

• CAS号: 176797-26-5
• MDL号: MFCD00948255

产品性质

• Empirical Formula (Hill Notation): C22H28N2O2S
• 纯度: ≥98% (HPLC)
• 外观: white to tan powder
• 比旋光度: [α]/D -140 to -170° in dichloromethane
• 溶解度: DMSO: ≥10 mg/mL
• 保存温度: 2-8°C

产品详细信息

详细说明 (简体中文)

Biochem/physiol Actions
S-17092 is a potent, selective inhibitor of Prolyl oligopeptidase (POP), also known as prolyl endopeptidase (PEP or PE). Ki=1.5 nM. Nootropic. S-17092 inhibition of POP prevents breakdown and thus increases the activity of a number of neuropeptides, which is likely the basis for its nootropic activity. S 17092 has been shown to improve cognition. It improved cognitive task performance in chronic low dose MPTP-treated monkeys. S-17092 was recently used to inhibit the formation of AcSDKP from its precursor 43-mer thymosin ?4 (T?4). Ac-SDKP is involved in hemopoietic stem cell differentiation, is pro-angiogenic and antifibrogenic.