ML133 hydrochloride

• 产品号: SML0190
• CAS号: 1222781-70-5
• 分子式: C19H20ClNO
• 分子量: 313.8212
• 纯 度: ≥95% (HPLC)

产品别名

• 标题: ML133 hydrochloride
• IUPAC标准名: [(4-methoxyphenyl)methyl](naphthalen-1-ylmethyl)amine hydrochloride
• IUPAC传统名: [(4-methoxyphenyl)methyl](naphthalen-1-ylmethyl)amine hydrochloride
• 别名: SID 85281105 hydrochloride; CID 781301 hydrochloride; N-(4-methoxybenzyl)-1-(naphthalen-1-yl)methanamine hydrochloride; VU0404943-1 hydrchloride; 1-(4-methoxyphenyl)-N-(naphthalen-1-ylmethyl)methanamine hydrochloride

产品登记号

• MDL号: MFCD20921521
• CAS号: 1222781-70-5

产品性质

• Empirical Formula (Hill Notation): C19H19NO · HCl
• 纯度: ≥95% (HPLC)
• 外观: white to tan powder
• 溶解度: DMSO: ≥10 mg/mL
• 保存温度: 2-8°C

产品详细信息

详细说明 (简体中文)

Biochem/physiol Actions
ML133 hydrochloride is a selective inhibitor of the Kir2 family of inward rectifier (IRK, KCNJ) potassium channels. ML133 inhibits Kir2.1 with IC50 of 1.8 μM at pH 7.4 and 290 nM at pH8.5. It exhibits little selectivity against other members of Kir2.x family channels, but has no effect on Kir1.1 (IC50 > 300 μM), and displays weak activity for Kir4.1 (76 μM) and Kir7.1 (33 μM), making ML133 the most selective small molecule inhibitor of the Kir family reported to date. It also showed modest selectivity versus hERG and a larger panel of GPCRs, ion channels and transporters.