TGN-020

• 产品号: SML0136
• CAS号: 51987-99-6
• 分子式: C8H6N4OS
• 分子量: 206.22444
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: TGN-020
• IUPAC标准名: N-(1,3,4-thiadiazol-2-yl)pyridine-3-carboxamide
• IUPAC传统名: N-(1,3,4-thiadiazol-2-yl)pyridine-3-carboxamide
• 别名: N-(1,3,4-Thiadiazol-2-yl)pyridine-3-carboxamide; N-(1,3,4-Thiadiazolyl)-m-nicotinamide; N-(1,3,4-Thiadiazol-2-yl)-3-pyridinecarboxamide; 2-(Nicotinamide)-1,3,4-thiadiazole

产品登记号

• CAS号: 51987-99-6
• MDL号: MFCD00708771

产品性质

• Empirical Formula (Hill Notation): C8H6N4OS
• 纯度: ≥98% (HPLC)
• 外观: white to tan powder
• 溶解度: DMSO: ≥8 mg/mL
• 保存温度: room temp

产品详细信息

详细说明 (简体中文)

Biochem/physiol Actions
TGN-020 is an inhibitor of Aquaporin 4 (AQP4), the most abundant water channel in brain. Aquaporins (AQPs) are water channels required for maintaining fluid homeostasis and enabling water movement across barrier membranes, but can enhance pathological cellular volume changes and cause edema in injury states. Pretreatment with the AQP4 inhibitor TGN-020 significantly reduced the volume of brain edema associated with ischemic injury in a mouse model of focal cerebral ischemia.