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Trilostane

产品号 SML0141 公司名称 Sigma Aldrich
CAS号 13647-35-3 公司网站 http://www.sigmaaldrich.com
分子式 C20H27NO3 电 话 1-800-521-8956
分子量 329.43328 传 真
纯 度 ≥98% (HPLC) 电子邮件
保 存 Chembase数据库ID: 979

产品价格信息

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产品别名

标题
Trilostane
IUPAC标准名
(1S,2R,6R,8S,11S,12S,15S,16S)-5,15-dihydroxy-2,16-dimethyl-7-oxapentacyclo[9.7.0.02,8.06,8.012,16]octadec-4-ene-4-carbonitrile
IUPAC传统名
trilostane
别名
(4α,5α,17β)-3,17-dihydroxy-4,5-epoxyandrost-2-ene-2-carbonitrile

产品登记号

CAS号 13647-35-3
MDL号 MFCD00199295

产品性质

Empirical Formula (Hill Notation) C20H27NO3
纯度 ≥98% (HPLC)
外观 white to tan powder
溶解度 DMSO: ≥17 mg/mL
MSDS下载 下载链接
保存温度 2-8°C

产品详细信息

详细说明 (简体中文)
Biochem/physiol Actions
Trilostane is an inhibitor of 3 β-hydroxysteroid dehydrogenase (3-β-HSD or delta 5-delta 4-isomerase), an essential enzyme for the biosynthesis of all classes of hormonal steroids. It has been used in the treatment of Cushing′s syndrome for stopping the production of cortisol, and is currently approved for dogs in the US, but is still a human drug in the UK and other countries. It is being investigated as a possible treatment for both breast cancer and prostate cancer to prevent the synthesis of estrogens and androgens from endogenous precursors. It has also been used to inhibit endogenous production of progesterone in research studies.

参考文献