VU591

• 产品号: SML0077
• CAS号: 1222810-74-3
• 分子式: C16H12N6O5
• 分子量: 368.30368
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: VU591
• IUPAC标准名: 6-nitro-2-{[(6-nitro-1H-1,3-benzodiazol-2-yl)methoxy]methyl}-1H-1,3-benzodiazole
• IUPAC传统名: 5-nitro-2-{[(5-nitro-3H-1,3-benzodiazol-2-yl)methoxy]methyl}-3H-1,3-benzodiazole
• 别名: 5-nitro-2-{[(6-nitro-1H-benzimidazol-2-yl)methoxy]methyl}-1H-benzimidazole; 2,2′-(oxydimethanediyl)bis(5-nitro-1H-benzimidazole); 2,2′-(oxydimethanediyl)bis(6-nitro-1H-benzimidazole)

产品登记号

• CAS号: 1222810-74-3

产品性质

• Empirical Formula (Hill Notation): C16H12N6O5
• 纯度: ≥98% (HPLC)
• 相关基因信息: human ... KCNJ1(3758)
• 外观: white to tan powder
• 溶解度: DMSO: ≥12 mg/mL
• 保存温度: 2-8°C

产品详细信息

详细说明 (简体中文)

Biochem/physiol Actions
VU591 is a Potassium Inwardly-Rectifying Channel (KCNJ1 or ROMK) specific inhibitor (IC50 = 240 nM) that is closely related to VU590. Unlike VU590, VU591 does not inhibit Kir7.1. The compound has a modest effect on Kir6.2/SUR1, causing 17% inhibition at 10 uM.