Conessine

• 产品号: SML0095
• CAS号: 546-06-5
• 分子式: C24H40N2
• 分子量: 356.5878
• 纯 度: ≥97% (HPLC)

产品别名

• 标题: Conessine
• IUPAC标准名: (1R,2S,5S,6S,9R,12S,13R,16S)-N,N,6,7,13-pentamethyl-7-azapentacyclo[10.8.0.0^2,^9.0^5,^9.0^1^3,^1^8]icos-18-en-16-amine
• IUPAC传统名: conessine
• 别名: Wrightine; NSC 119994; (3β)-N,N-dimethyl-con-5-enin-3-amine; Conessin; Neriine; Roquessine

产品登记号

• CAS号: 546-06-5
• MDL号: MFCD00016752
• EC号: 208-897-2

产品性质

• Empirical Formula (Hill Notation): C24H40N2
• 纯度: ≥97% (HPLC)
• 外观: white to tan powder
• 溶解度: ethanol: ≥2 mg/mL
• 保存温度: 2-8°C

产品详细信息

详细说明 (简体中文)

Biochem/physiol Actions
Conessine is a plant steroid alkaloid that acts as a potent and specific antagonist of histamine H3 receptors (Ki = 5.37 and 24.5 nM for human and rat receptors, respectively). Conessine is 1860-fold selective for H3 over H4 and does not bind to H1 or H2 receptors. The molecule also binds to the human α2C4 adrenergic receptor (pKi = 7.98).