Perhexiline maleate salt

• 产品号: SML0120
• CAS号: 6724-53-4
• 分子式: C23H39NO4
• 分子量: 393.56006
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: Perhexiline maleate salt
• IUPAC标准名: 2-(2,2-dicyclohexylethyl)piperidine; but-2-enedioic acid
• IUPAC传统名: butenedioic acid; perhexiline
• 别名: 2-(2,2-Dicyclohexylethyl)piperidine

产品登记号

• MDL号: MFCD00057329
• CAS号: 6724-53-4

产品性质

• Empirical Formula (Hill Notation): C19H35N · C4H4O4
• 纯度: ≥98% (HPLC)
• 外观: white to tan powder
• 溶解度: DMSO: ≥5 mg/mL
• 保存温度: 2-8°C

产品详细信息

详细说明 (简体中文)

Biochem/physiol Actions
Perhexiline maleate is an anti-anginal metabolic modulator. It inhibits the mitochondrial enzyme carnitine palmitoyltransferase CPT-1 and to a lesser extent CPT-2. This causes a shift in myocardial substrate utilisation from long chain fatty acids to carbohydrates, resulting in increased glucose and lactate utilization and increased ATP production for the same O2 consumption as before and consequently increases myocardial efficiency. Perhexiline maleate was also recently found to inhibit the activity of mTORC1.