TFLLR-NH2 trifluoroacetate salt

• 产品号: T7830
• 分子式: C33H54F3N9O8
• 分子量: 761.8325696
• 纯 度: >98% (HPLC)

产品别名

• 标题: TFLLR-NH2 trifluoroacetate salt
• IUPAC标准名: (2S)-2-[(2S)-2-[(2S,3R)-2-amino-3-hydroxybutanamido]-3-phenylpropanamido]-N-[(1S)-1-{[(1S)-4-carbamimidamido-1-carbamoylbutyl]carbamoyl}-3-methylbutyl]-4-methylpentanamide; trifluoroacetic acid
• IUPAC传统名: (2S)-2-[(2S)-2-[(2S,3R)-2-amino-3-hydroxybutanamido]-3-phenylpropanamido]-N-[(1S)-1-{[(1S)-4-carbamimidamido-1-carbamoylbutyl]carbamoyl}-3-methylbutyl]-4-methylpentanamide; trifluoroacetic acid
• 别名: L-Threonyl-L-phenylalanyl-L-leucyl-L-leucyl- L-argininamide trifluoroacetate salt; Thr-Phe-Leu-Leu-Arg-NH2 trifluoroacetate salt

产品登记号

• MDL号: MFCD05663482

产品性质

• Empirical Formula (Hill Notation): C31H53N9O6 · xC2HF3O2
• 纯度: >98% (HPLC)
• 外观: white to tan lyophilized powder
• 溶解度: H2O: >2 mg/mL
• 保存温度: -20°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Amino Acid Sequence
Thr-Phe-Leu-Leu-Arg-NH2
Biochem/physiol Actions
TFLLR-NH2 is a protease-activated receptor (PARs) agonist which is more selective to PAR-1 than SFLLRN-NH2. Protease-activated receptors (PARs) are present on various organs including, plateles, mast cell, gallblader, oesophagus etc, and regulate various physiological processes including human platelet aggregation, vascular contraction/relaxation, and an increase in endothelial permeability. Recent papers indicated that PAR′s are also involved in sensory processing. Specificly PAR ligands enhance glutamatergic excitatory transmission in substantia gelatinosa (SG) neurons of adult rat spinal cord slices.

详细说明 (简体中文)

Amino Acid Sequence
Thr-Phe-Leu-Leu-Arg-NH2
Biochem/physiol Actions
TFLLR-NH2 is a protease-activated receptor (PARs) agonist which is more selective to PAR-1 than SFLLRN-NH2. Protease-activated receptors (PARs) are present on various organs including, plateles, mast cell, gallblader, oesophagus etc, and regulate various physiological processes including human platelet aggregation, vascular contraction/relaxation, and an increase in endothelial permeability. Recent papers indicated that PAR′s are also involved in sensory processing. Specificly PAR ligands enhance glutamatergic excitatory transmission in substantia gelatinosa (SG) neurons of adult rat spinal cord slices.