NN-DNJ

• 产品号: N6414
• CAS号: 81117-35-3
• 分子式: C15H31NO4
• 分子量: 289.41094
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: NN-DNJ
• IUPAC标准名: (2R,3R,4R,5S)-2-(hydroxymethyl)-1-nonylpiperidine-3,4,5-triol
• IUPAC传统名: (2R,3R,4R,5S)-2-(hydroxymethyl)-1-nonylpiperidine-3,4,5-triol

产品登记号

• MDL号: MFCD00905846
• CAS号: 81117-35-3

产品性质

• Empirical Formula (Hill Notation): C15H31NO4
• 纯度: ≥98% (HPLC)
• 外观: solid
• 溶解度: DMSO: >10 mg/mL
• GHS警示词: Warning
• GHS危险声明: H319
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves
• GHS警示性声明: P305 + P351 + P338
• 危险公开号: 36
• 安全公开号: 26
• 保存温度: -20°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
NN-DNJ is a glucosidase inhibitor that acts as a pharmacologic chaperone. NN-DNJ also acts synergistically with proteostasis modulators such as celastrol and MG132 to stabilize mutant proteins in properly folded states. NN-DNJ stabilizes various proteins against misfolding, increasing proper trafficking from the endoplasmic reticulum. There is potential use in studying diseases marked by misfolded proteins and has shown antiviral activity.

详细说明 (简体中文)

Biochem/physiol Actions
NN-DNJ is a glucosidase inhibitor that acts as a pharmacologic chaperone. NN-DNJ also acts synergistically with proteostasis modulators such as celastrol and MG132 to stabilize mutant proteins in properly folded states. NN-DNJ stabilizes various proteins against misfolding, increasing proper trafficking from the endoplasmic reticulum. There is potential use in studying diseases marked by misfolded proteins and has shown antiviral activity.