Garcinol

• 产品号: G5173
• CAS号: 78824-30-3
• 分子式: C38H50O6
• 分子量: 602.8
• 纯 度: ≥95%

产品别名

• 标题: Garcinol
• IUPAC标准名: (1R,5R,7R)-3-(3,4-dihydroxybenzoyl)-4-hydroxy-8,8-dimethyl-5-[(2S)-5-methyl-2-(prop-1-en-2-yl)hex-4-en-1-yl]-1,7-bis(3-methylbut-2-en-1-yl)bicyclo[3.3.1]non-3-ene-2,9-dione
• IUPAC传统名: garcinol
• 别名: Camboginol; (1R,5R,7R)-3-(3,4-Dihydroxybenzoyl)-4-hydroxy-8,8-dimethyl-1,7-bis(3-methyl-2-buten-1-yl)-5-[(2S)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-Bicyclo[3.3.1]non-3-ene-2,9-dione

产品登记号

• CAS号: 78824-30-3
• MDL号: MFCD03700761

产品性质

• Empirical Formula (Hill Notation): C38H50O6
• 纯度: ≥95%
• 外观: powder, yellow
• 溶解度: : >5 mg/mL
• 保存温度: -20°C

产品详细信息

详细说明 (简体中文)

Biochem/physiol Actions
Garcinol is a HAT (histone acetyltransferase) inhibitor. Garcinol is anti-inflammatory and anti-carcinogenic. Histone acetyltransferases provide opposing enzymatic mechanisms for chromatin remodeling and epigenetic control of gene expression. HATs are involved in regulation of transformation, transcription, differentiation, apoptosis, embryonic development and oncogenesis. IC50 p300 = 7 mM; IC50 PCAF = 5 mM (similar to anacardic acid). Garcinol is highly toxic compared to LTK-14, and does not discriminate between p300 and PCAF.